ID   HRSL3_HUMAN             Reviewed;         162 AA.
AC   P53816; Q3SYI3; Q9HDD1;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 2.
DT   23-JAN-2007, entry version 48.
DE   HRAS-like suppressor 3 (H-rev 107 protein homolog) (HREV107-3) (Renal
DE   carcinoma antigen NY-REN-65).
GN   Name=HRASLS3; Synonyms=HREV107;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Liver;
RX   MEDLINE=98442971; PubMed=9771974; DOI=10.1038/sj.onc.1202060;
RA   Husmann K., Sers C., Fietze E., Mincheva A., Lichter P., Schafer R.;
RT   "Transcriptional and translational downregulation of H-REV107, a class
RT   II tumour suppressor gene located on human chromosome 11q11-12.";
RL   Oncogene 17:1305-1312(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kato S.;
RT   "Human cDNA encoding H-REV107 protein homolog.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Siegrist S., Feral C., Chami M., Solhonne B., Rajpert-De Meyts E.,
RA   Guellaen G., Bulle F.;
RT   "Homo sapiens testis HREV107-3 mRNA.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION AS A RENAL CANCER ANTIGEN.
RC   TISSUE=Renal cell carcinoma;
RX   MEDLINE=99438124; PubMed=10508479;
RX   DOI=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5;
RA   Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H.,
RA   Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T.,
RA   Old L.J.;
RT   "Antigens recognized by autologous antibody in patients with renal-
RT   cell carcinoma.";
RL   Int. J. Cancer 83:456-464(1999).
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=11973642; DOI=10.1038/sj.onc.1205377;
RA   Sers C., Husmann K., Nazarenko I., Reich S., Wiechen K.,
RA   Zhumabayeva B., Adhikari P., Schroder K., Gontarewicz A., Schafer R.;
RT   "The class II tumour suppressor gene H-REV107-1 is a target of
RT   interferon-regulatory factor-1 and is involved in IFNgamma-induced
RT   cell death in human ovarian carcinoma cells.";
RL   Oncogene 21:2829-2839(2002).
CC   -!- FUNCTION: Tumor suppressor that may be involved in interferon-
CC       dependent cell death.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed with the exception of
CC       haematopoetic cells. Consistently down-regulated in tumorigenic
CC       human cell lines. Found in normal ovarian epithelial cells but
CC       down-regulated in ovarian carcinomas.
CC   -!- SIMILARITY: Belongs to the H-rev107 family.
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DR   EMBL; X92814; CAA63423.1; -; mRNA.
DR   EMBL; AB030814; BAB08108.1; -; mRNA.
DR   EMBL; AF317086; AAL26892.1; -; mRNA.
DR   EMBL; BC001387; AAH01387.1; -; mRNA.
DR   EMBL; BC103807; AAI03808.1; -; mRNA.
DR   Ensembl; ENSG00000176485; Homo sapiens.
DR   KEGG; hsa:11145; -.
DR   H-InvDB; HIX0019647; -.
DR   HGNC; HGNC:17825; HRASLS3.
DR   LinkHub; P53816; -.
DR   ArrayExpress; P53816; -.
DR   GermOnline; ENSG00000176485; Homo sapiens.
DR   RZPD-ProtExp; I0553; -.
DR   RZPD-ProtExp; IOH3962; -.
DR   RZPD-ProtExp; RZPDo839B04149; -.
DR   RZPD-ProtExp; RZPDo839B04150; -.
DR   InterPro; IPR007053; NC.
DR   Pfam; PF04970; NC; 1.
KW   Anti-oncogene; Cell cycle; Membrane; Transmembrane.
FT   CHAIN         1    162       HRAS-like suppressor 3.
FT                                /FTId=PRO_0000152484.
FT   TRANSMEM    134    154       Potential.
FT   CONFLICT     90     90       S -> T (in Ref. 1).
SQ   SEQUENCE   162 AA;  17937 MW;  3565BFC756A6DA3C CRC64;
     MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV
     KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL
     RYGVARSDQV RDVIIAASVA GMGLAAMSLI GVMFSRNKRQ KQ
//