ID HOL1_YEAST Reviewed; 586 AA. AC P53389; D6W1N0; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 31-OCT-2012, entry version 89. DE RecName: Full=Protein HOL1; GN Name=HOL1; OrderedLocusNames=YNR055C; ORFNames=N3494; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=97113542; PubMed=8955402; RA Wright M.B., Howell E.A., Gaber R.F.; RT "Amino acid substitutions in membrane-spanning domains of Hol1, a RT member of the major facilitator superfamily of transporters, confer RT nonselective cation uptake in Saccharomyces cerevisiae."; RL J. Bacteriol. 178:7197-7205(1996). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX MEDLINE=97313269; PubMed=9169873; RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F., RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., RA Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., RA Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., RA Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., RA Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., RA Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., RA Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., RA Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., RA Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., RA Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., RA Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., RA Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., RA Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., RA Wambutt R., Wedler H., Zollner A., Hani J.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV RT and its evolutionary implications."; RL Nature 387:93-98(1997). RN [3] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RG Saccharomyces Genome Database; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [4] RP TOPOLOGY [LARGE SCALE ANALYSIS]. RC STRAIN=ATCC 208353 / W303-1A; RX PubMed=16847258; DOI=10.1073/pnas.0604075103; RA Kim H., Melen K., Oesterberg M., von Heijne G.; RT "A global topology map of the Saccharomyces cerevisiae membrane RT proteome."; RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006). CC -!- FUNCTION: Seems to be involved in the uptake of several cations CC and of histidinol. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein CC (Probable). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42348; AAB47713.1; -; Genomic_DNA. DR EMBL; Z71670; CAA96336.1; -; Genomic_DNA. DR EMBL; Z71671; CAA96338.1; -; Genomic_DNA. DR EMBL; BK006947; DAA10596.1; -; Genomic_DNA. DR PIR; S63386; S63386. DR RefSeq; NP_014453.3; NM_001183232.3. DR ProteinModelPortal; P53389; -. DR DIP; DIP-7266N; -. DR IntAct; P53389; 1. DR STRING; P53389; -. DR TCDB; 2.A.1.2.33; major facilitator superfamily (MFS). DR EnsemblFungi; YNR055C; YNR055C; YNR055C. DR GeneID; 855792; -. DR KEGG; sce:YNR055C; -. DR CYGD; YNR055c; -. DR SGD; S000005338; HOL1. DR eggNOG; COG0477; -. DR GeneTree; ENSGT00620000088227; -. DR HOGENOM; HOG000248534; -. DR OMA; IYVGLGF; -. DR OrthoDB; EOG4X3M8K; -. DR NextBio; 980282; -. DR ArrayExpress; P53389; -. DR Genevestigator; P53389; -. DR GermOnline; YNR055C; Saccharomyces cerevisiae. DR GO; GO:0016021; C:integral to membrane; ISM:SGD. DR GO; GO:0005739; C:mitochondrion; IDA:SGD. DR GO; GO:0005886; C:plasma membrane; ISS:SGD. DR GO; GO:0015665; F:alcohol transmembrane transporter activity; IMP:SGD. DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IMP:SGD. DR InterPro; IPR011701; MFS. DR InterPro; IPR016196; MFS_dom_general_subst_transpt. DR Pfam; PF07690; MFS_1; 1. DR SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1. PE 1: Evidence at protein level; KW Complete proteome; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 586 Protein HOL1. FT /FTId=PRO_0000084026. FT TOPO_DOM 1 66 Extracellular (Potential). FT TRANSMEM 67 87 Helical; (Potential). FT TOPO_DOM 88 103 Cytoplasmic (Potential). FT TRANSMEM 104 124 Helical; (Potential). FT TOPO_DOM 125 130 Extracellular (Potential). FT TRANSMEM 131 151 Helical; (Potential). FT TOPO_DOM 152 189 Cytoplasmic (Potential). FT TRANSMEM 190 210 Helical; (Potential). FT TOPO_DOM 211 219 Extracellular (Potential). FT TRANSMEM 220 240 Helical; (Potential). FT TOPO_DOM 241 362 Cytoplasmic (Potential). FT TRANSMEM 363 383 Helical; (Potential). FT TOPO_DOM 384 413 Extracellular (Potential). FT TRANSMEM 414 434 Helical; (Potential). FT TOPO_DOM 435 448 Cytoplasmic (Potential). FT TRANSMEM 449 469 Helical; (Potential). FT TOPO_DOM 470 477 Extracellular (Potential). FT TRANSMEM 478 498 Helical; (Potential). FT TOPO_DOM 499 508 Cytoplasmic (Potential). FT TRANSMEM 509 529 Helical; (Potential). FT TOPO_DOM 530 544 Extracellular (Potential). FT TRANSMEM 545 565 Helical; (Potential). FT TOPO_DOM 566 586 Cytoplasmic (Potential). FT CONFLICT 510 510 L -> F (in Ref. 1; AAB47713). SQ SEQUENCE 586 AA; 65348 MW; BEB6415256C3600F CRC64; MDKYTNRDHP DYIPGTFNIY SSQNLENGII YESKLKKTSS GVVLIPQPSY SPNDPLNWSS WRKLAHFGLM AFITAFTAAT SNDAGAAQDS LNEIYGISYD SMNTGAGVLF LGIGWSTLFL APFANLYGRK ITYIVCTTLG LFGALWFALA KRTSDTIWSQ LFVGISESCA EAQVQLSLSD IFFQHQLGSV LTVYIMCTSI GTFLGPLIAG YISAFTNFRW VGWVAVIISG GLLITIIFGC EETYFDRGQY MTPLTSCQSG YEDGTTLQNS DNTAVSRRKR HLDAKLSTPG AMGEKGVDLS ETAEFEVNNE EEVTIPETRE LIDGSKEHLK PYPKRVAILT KATNLKGYGF KQYFKYLKIN LRMFLFPPVW LSGMFWGIQD VFLTFYLTTQ ESAYYEPPWN YSDFGVAIMN VPTLIGAVIG CICAGIVSDY FVLWMARHNR GILEAEFRLY FSIATAIIGP AGLLMFGIGT ARQWPWQAIY VGLGFVGFAW GCSGDIAMAY LMDCYPDMVL EGMVCTAIIN NTISCIFTFT CSDWLAASGT ENTYIALAVI NFGITAFALP MYYYGKRIRL WTKRWYLQSV NLRDGV //