ID   8ODP_RAT                Reviewed;         156 AA.
AC   P53369;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   28-JUL-2009, entry version 50.
DE   RecName: Full=7,8-dihydro-8-oxoguanine triphosphatase;
DE            EC=3.6.1.-;
DE   AltName: Full=8-oxo-dGTPase;
DE   AltName: Full=Nucleoside diphosphate-linked moiety X motif 1;
DE            Short=Nudix motif 1;
GN   Name=Nudt1; Synonyms=Mth1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Donryu; TISSUE=Spleen;
RX   MEDLINE=96033912; PubMed=7586133; DOI=10.1093/carcin/16.10.2343;
RA   Cai J.P., Kakuma T., Tsuzuki T., Sekiguchi M.;
RT   "cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents
RT   occurrence of spontaneous mutations due to oxidation of guanine
RT   nucleotides.";
RL   Carcinogenesis 16:2343-2350(1995).
CC   -!- FUNCTION: Antimutagenic. Responsible for preventing
CC       misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
CC       transversions.
CC   -!- CATALYTIC ACTIVITY: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family.
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DR   EMBL; D49977; BAA08726.1; -; mRNA.
DR   EMBL; D49980; BAA08727.1; -; Genomic_DNA.
DR   IPI; IPI00209189; -.
DR   RefSeq; NP_476461.1; -.
DR   UniGene; Rn.10669; -.
DR   SMR; P53369; 1-154.
DR   Ensembl; ENSRNOT00000001700; ENSRNOP00000001700; ENSRNOG00000001260; Rattus norvegicus.
DR   GeneID; 117260; -.
DR   KEGG; rno:117260; -.
DR   UCSC; NM_057120; rat.
DR   RGD; 621080; Nudt1.
DR   HOVERGEN; P53369; -.
DR   OMA; P53369; DVHIFRT.
DR   NextBio; 620134; -.
DR   ArrayExpress; P53369; -.
DR   GermOnline; ENSRNOG00000001260; Rattus norvegicus.
DR   GO; GO:0008413; F:8-oxo-7,8-dihydroguanine triphosphatase act...; NAS:RGD.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   InterPro; IPR003563; 8Ox_triPHTase.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR020084; NUDIX_hydrolase_dom_CS.
DR   Gene3D; G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   PRINTS; PR01403; 8OXTPHPHTASE.
DR   PROSITE; PS00893; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase.
FT   CHAIN         1    156       7,8-dihydro-8-oxoguanine triphosphatase.
FT                                /FTId=PRO_0000057101.
FT   MOTIF        37     58       Nudix box.
SQ   SEQUENCE   156 AA;  18018 MW;  60AFB6522CB03E18 CRC64;
     MSTSRLYTLV LVLQPQRVLL GMKKRGFGAG RWNGFGGKVQ EGETIEDGAK RELLEESGLR
     VDTLHKVGHI SFEFVGSPEL MDVHIFSTDH VHGTPTESEE MRPQWFQLDQ IPFADMWPDD
     SYWFPLLLQK KKFCGHFKFH GQDTILSYSL REVDEF
//