ID HMGC_HUMAN STANDARD; PRT; 109 AA. AC P52926; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE HIGH MOBILITY GROUP PROTEIN HMGI-C. GN HMGIC. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hepatoma; RX MEDLINE=94257023; PubMed=8198613; RA Patel U.A., Bandiera A., Manfioletti G., Giancotti V., Chau K.-Y., RA Crane-Robinson C.; RT "Expression and cDNA cloning of human HMGI-C phosphoprotein."; RL Biochem. Biophys. Res. Commun. 201:63-70(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=96091170; PubMed=7501444; RA Chau K.-Y., Patel U.A., Lee K.-L.D., Lam H.-Y.P., Crane-Robinson C.; RT "The gene for the human architectural transcription factor HMGI-C RT consists of five exons each coding for a distinct functional RT element."; RL Nucleic Acids Res. 23:4262-4266(1995). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=95400325; PubMed=7670494; RA Schoenmakers E.F.P.M., Wanschura S., Mols R., Bullerdiek J., RA van den Berghe H., van de Ven W.J.M.; RT "Recurrent rearrangements in the high mobility group protein gene, RT HMGI-C, in benign mesenchymal tumours."; RL Nat. Genet. 10:436-444(1995). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE=96422186; PubMed=8824803; RA Ashar H.R., Cherath L., Przysybz K., Chada K.; RT "Genomic characterization of human HMGIC, a member of the accessory RT transcription factor family found at translocation breakpoints in RT lipomas."; RL Genomics 31:207-214(1996). CC -!- FUNCTION: INVOLVED IN TRANSCRIPTION REGULATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- DEVELOPMENTAL STAGE: EXPRESSED PREDOMINANTLY DURING EMBRYOGENESIS. CC -!- PTM: REGULATED BY CELL CYCLE-DEPENDENT PHOSPHORYLATION WHICH CC ALTERS ITS DNA BINDING AFFINITY. CC -!- DISEASE: HMGIC IS FUSED WITH A NUMBER OF OTHER GENES IN LIPOMAS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L46353; AAA96484.1; -. DR EMBL; L41044; AAA96484.1; JOINED. DR EMBL; L44578; AAA96484.1; JOINED. DR EMBL; Z31595; CAA83472.1; -. DR EMBL; U28749; AAA68613.1; -. DR EMBL; U28754; AAA68614.1; -. DR EMBL; U28750; AAA68614.1; JOINED. DR EMBL; U28751; AAA68614.1; JOINED. DR EMBL; U28752; AAA68614.1; JOINED. DR EMBL; U28753; AAA68614.1; JOINED. DR EMBL; X92518; CAA63295.1; -. DR HSSP; P10910; 2EZD. DR MIM; 600698; -. DR InterPro; IPR000116; -. DR InterPro; IPR000637; -. DR PRINTS; PR00929; ATHOOK. DR PRINTS; PR00930; HIGHMOBLTYIY. DR PROSITE; PS00354; HMGI_Y; 2. KW Nuclear protein; Chromosomal protein; DNA-binding; Repeat; KW Transcription regulation; Phosphorylation; Chromosomal translocation; KW Proto-oncogene. FT DNA_BIND 24 34 A.T HOOK. FT DNA_BIND 44 54 A.T HOOK. FT DNA_BIND 71 91 A.T HOOK. SQ SEQUENCE 109 AA; 11832 MW; F36BABE623DA4615 CRC64; MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED //