ID HMGC_HUMAN STANDARD; PRT; 109 AA. AC P52926; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE HIGH MOBILITY GROUP PROTEIN HMGI-C. GN HMGIC. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=HEPATOMA; RX MEDLINE; 94257023. RA PATEL U.A., BANDIERA A., MANFIOLETTI G., GIANCOTTI V., CHAU K.-Y., RA CRANE-ROBINSON C.; RT "Expression and cDNA cloning of human HMGI-C phosphoprotein."; RL Biochem. Biophys. Res. Commun. 201:63-70(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 96091170. RA CHAU K.-Y., PATEL U.A., LEE K.-L.D., LAM H.-Y.P., CRANE-ROBINSON C.; RT "The gene for the human architectural transcription factor HMGI-C RT consists of five exons each coding for a distinct functional RT element."; RL Nucleic Acids Res. 23:4262-4266(1995). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 95400325. RA SCHOENMAKERS E.F.P.M., WANSCHURA S., MOLS R., BULLERDIEK J., RA VAN DEN BERGHE H., VAN DE VEN W.J.M.; RT "Recurrent rearrangements in the high mobility group protein gene, RT HMGI-C, in benign mesenchymal tumours."; RL Nat. Genet. 10:436-444(1995). RN [4] RP SEQUENCE FROM N.A. RX MEDLINE; 96422186. RA ASHAR H.R., CHERATH L., PRZYSYBZ K., CHADA K.; RT "Genomic characterization of human HMGIC, a member of the accessory RT transcription factor family found at translocation breakpoints in RT lipomas."; RL Genomics 31:207-214(1996). CC -!- FUNCTION: INVOLVED IN TRANSCRIPTION REGULATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- DEVELOPMENTAL STAGE: EXPRESSED PREDOMINANTLY DURING EMBRYOGENESIS. CC -!- PTM: REGULATED BY CELL CYCLE-DEPENDENT PHOSPHORYLATION WHICH CC ALTERS ITS DNA BINDING AFFINITY. CC -!- DISEASE: HMGIC IS FUSED WITH A NUMBER OF OTHER GENES IN LIPOMAS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L46353; AAA96484.1; -. DR EMBL; L41044; AAA96484.1; JOINED. DR EMBL; L44578; AAA96484.1; JOINED. DR EMBL; Z31595; CAA83472.1; -. DR EMBL; U28749; AAA68613.1; -. DR EMBL; U28754; AAA68614.1; -. DR EMBL; U28750; AAA68614.1; JOINED. DR EMBL; U28751; AAA68614.1; JOINED. DR EMBL; U28752; AAA68614.1; JOINED. DR EMBL; U28753; AAA68614.1; JOINED. DR EMBL; X92518; CAA63295.1; -. DR HSSP; P10910; 2EZD. DR MIM; 600698; -. DR PROSITE; PS00354; HMGI_Y; 2. KW Nuclear protein; Chromosomal protein; DNA-binding; Repeat; KW Transcription regulation; Phosphorylation; Chromosomal translocation; KW Proto-oncogene. FT DNA_BIND 24 34 A.T HOOK. FT DNA_BIND 44 54 A.T HOOK. FT DNA_BIND 71 91 A.T HOOK. SQ SEQUENCE 109 AA; 11832 MW; A02A435F CRC32; MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEED //