ID IF_MOUSE Reviewed; 417 AA. AC P52787; Q8C5C1; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 03-MAR-2009, sequence version 2. DT 24-MAR-2009, entry version 60. DE RecName: Full=Gastric intrinsic factor; DE AltName: Full=Intrinsic factor; DE Short=INF; DE Short=IF; DE Flags: Precursor; GN Name=Gif; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC STRAIN=BALB/c; TISSUE=Stomach; RX MEDLINE=94075347; PubMed=8253786; RA Lorenz R.G., Gordon J.I.; RT "Use of transgenic mice to study regulation of gene expression in the RT parietal cell lineage of gastric units."; RL J. Biol. Chem. 268:26559-26570(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Cecum; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Promotes absorption of the essential vitamin cobalamin CC (Cbl) in the ileum by specific receptor-mediated endocytosis. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Gastric mucosa. CC -!- SIMILARITY: Belongs to the eukaryotic cobalamin transport proteins CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L24192; AAA37881.1; -; Genomic_DNA. DR EMBL; L24191; AAA37882.1; -; mRNA. DR EMBL; AK078933; BAC37468.1; -; mRNA. DR EMBL; CH466534; EDL41439.1; -; Genomic_DNA. DR EMBL; BC118519; AAI18520.1; -; mRNA. DR IPI; IPI00387294; -. DR PIR; A49684; A49684. DR RefSeq; NP_032144.2; -. DR UniGene; Mm.456; -. DR Ensembl; ENSMUSG00000024682; Mus musculus. DR GeneID; 14603; -. DR MGI; MGI:1202394; Gif. DR HOGENOM; P52787; -. DR HOVERGEN; P52787; -. DR ArrayExpress; P52787; -. DR Bgee; P52787; -. DR CleanEx; MM_GIF; -. DR GermOnline; ENSMUSG00000024682; Mus musculus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro. DR GO; GO:0050897; F:cobalt ion binding; IEA:UniProtKB-KW. DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-KW. DR GO; GO:0015889; P:cobalamin transport; IEA:InterPro. DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW. DR InterPro; IPR002157; Cbl-bd_transpt_euk. DR PANTHER; PTHR10559; Cobalamin_bd; 1. DR Pfam; PF01122; Cobalamin_bind; 1. DR PROSITE; PS00468; COBALAMIN_BINDING; 1. PE 2: Evidence at transcript level; KW Cobalt; Cobalt transport; Disulfide bond; Glycoprotein; Ion transport; KW Secreted; Signal; Transport. FT SIGNAL 1 18 Potential. FT CHAIN 19 417 Gastric intrinsic factor. FT /FTId=PRO_0000005559. FT CARBOHYD 311 311 N-linked (GlcNAc...) (Potential). FT CARBOHYD 330 330 N-linked (GlcNAc...) (Potential). FT CARBOHYD 413 413 N-linked (GlcNAc...) (Potential). FT DISULFID 26 246 By similarity. FT DISULFID 103 288 By similarity. FT DISULFID 143 182 By similarity. FT CONFLICT 86 86 D -> N (in Ref. 1; AAA37881/AAA37882). FT CONFLICT 156 156 R -> A (in Ref. 1; AAA37881/AAA37882). FT CONFLICT 327 327 L -> P (in Ref. 1; AAA37881/AAA37882). SQ SEQUENCE 417 AA; 45497 MW; BF38663EFC90F34A CRC64; MAWLTLYLLS VLWAVAGTST RAQSSCSVPP DQQPWVDGLQ ALMENSVTDS DFPNPSILIA MNLAGAYNVE AQKLLTYQLM ASDSADLTSG QLALTVMALT SSCRDPGSKV STLLKKMENW SPSSPGAESS AFYGPGLAIL ALCQKSSEAT LPIAVRFAKT LMMEPSPFNV DTGAVATLAL TCMYNKIPVG SQENYRDLFG QALKAIVEKI SLRIKADGII GDIYSTGLAM QALSVTPEQP TKKWDCEKTM HTILNEIKQG KFQNPMSIAQ ILPSLKGKTY LDVPQVTCGP DHEVPPTLTD YPTPVPTSVS NITVIYTINN QLRGVDLLFN VTIEVSVKSG SVLLAVLEEA QRKNSMFKFE TTMTSWGLIV SSINNIAENV NHKTYWEFLS GKTPLDEGVA YYIPFNHEHI TANFTQY //