ID IF_MOUSE STANDARD; PRT; 417 AA. AC P52787; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE INTRINSIC FACTOR PRECURSOR (IF) (INF) (GASTRIC INTRINSIC FACTOR). GN GIF. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/C; TISSUE=STOMACH; RX MEDLINE; 94075347. RA LORENZ R.G., GORDON J.I.; RT "Use of transgenic mice to study regulation of gene expression in the RT parietal cell lineage of gastric units."; RL J. Biol. Chem. 268:26559-26570(1993). CC -!- FUNCTION: PROMOTES ABSORPTION OF THE ESSENTIAL VITAMIN COBALAMIN CC (CBL) IN THE ILEUM BY SPECIFIC RECEPTOR-MEDIATED ENDOCYTOSIS. CC -!- TISSUE SPECIFICITY: GASTRIC MUCOSA. CC -!- SIMILARITY: BELONGS TO THE EUKARYOTIC COBALAMIN TRANSPORT PROTEINS CC FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L24191; AAA37882.1; -. DR MGD; MGI:1202394; GIF. DR PFAM; PF01122; Cobalamin_bind; 1. DR PROSITE; PS00468; COBALAMIN_BINDING; 1. KW Cobalt transport; Glycoprotein; Signal. FT SIGNAL 1 18 POTENTIAL. FT CHAIN 19 417 INTRINSIC FACTOR. FT CARBOHYD 86 86 POTENTIAL. FT CARBOHYD 311 311 POTENTIAL. FT CARBOHYD 330 330 POTENTIAL. FT CARBOHYD 413 413 POTENTIAL. SQ SEQUENCE 417 AA; 45395 MW; 9F3E7C19 CRC32; MAWLTLYLLS VLWAVAGTST RAQSSCSVPP DQQPWVDGLQ ALMENSVTDS DFPNPSILIA MNLAGAYNVE AQKLLTYQLM ASDSANLTSG QLALTVMALT SSCRDPGSKV STLLKKMENW SPSSPGAESS AFYGPGLAIL ALCQKSSEAT LPIAVAFAKT LMMEPSPFNV DTGAVATLAL TCMYNKIPVG SQENYRDLFG QALKAIVEKI SLRIKADGII GDIYSTGLAM QALSVTPEQP TKKWDCEKTM HTILNEIKQG KFQNPMSIAQ ILPSLKGKTY LDVPQVTCGP DHEVPPTLTD YPTPVPTSVS NITVIYTINN QLRGVDPLFN VTIEVSVKSG SVLLAVLEEA QRKNSMFKFE TTMTSWGLIV SSINNIAENV NHKTYWEFLS GKTPLDEGVA YYIPFNHEHI TANFTQY //