ID IF_MOUSE STANDARD; PRT; 417 AA. AC P52787; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Gastric intrinsic factor precursor (Intrinsic factor) (IF) (INF). GN Name=Gif; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; TISSUE=Stomach; RX MEDLINE=94075347; PubMed=8253786; RA Lorenz R.G., Gordon J.I.; RT "Use of transgenic mice to study regulation of gene expression in the RT parietal cell lineage of gastric units."; RL J. Biol. Chem. 268:26559-26570(1993). CC -!- FUNCTION: Promotes absorption of the essential vitamin cobalamin CC (Cbl) in the ileum by specific receptor-mediated endocytosis. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Gastric mucosa. CC -!- SIMILARITY: Belongs to the eukaryotic cobalamin transport proteins CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L24191; AAA37882.1; -; mRNA. DR EMBL; L24192; AAA37881.1; -; Genomic_DNA. DR PIR; A49684; A49684. DR Ensembl; ENSMUSG00000024682; Mus musculus. DR MGI; MGI:1202394; Gif. DR GO; GO:0005615; C:extracellular space; TAS. DR InterPro; IPR002157; Cobalamin_bind. DR Pfam; PF01122; Cobalamin_bind; 1. DR PROSITE; PS00468; COBALAMIN_BINDING; 1. KW Cobalt; Cobalt transport; Glycoprotein; Ion transport; Signal; KW Transport. FT SIGNAL 1 18 Potential. FT CHAIN 19 417 Gastric intrinsic factor. FT CARBOHYD 86 86 N-linked (GlcNAc...) (Potential). FT CARBOHYD 311 311 N-linked (GlcNAc...) (Potential). FT CARBOHYD 330 330 N-linked (GlcNAc...) (Potential). FT CARBOHYD 413 413 N-linked (GlcNAc...) (Potential). FT DISULFID 26 246 By similarity. FT DISULFID 103 288 By similarity. FT DISULFID 143 182 By similarity. SQ SEQUENCE 417 AA; 45395 MW; 421713BAE6358DC2 CRC64; MAWLTLYLLS VLWAVAGTST RAQSSCSVPP DQQPWVDGLQ ALMENSVTDS DFPNPSILIA MNLAGAYNVE AQKLLTYQLM ASDSANLTSG QLALTVMALT SSCRDPGSKV STLLKKMENW SPSSPGAESS AFYGPGLAIL ALCQKSSEAT LPIAVAFAKT LMMEPSPFNV DTGAVATLAL TCMYNKIPVG SQENYRDLFG QALKAIVEKI SLRIKADGII GDIYSTGLAM QALSVTPEQP TKKWDCEKTM HTILNEIKQG KFQNPMSIAQ ILPSLKGKTY LDVPQVTCGP DHEVPPTLTD YPTPVPTSVS NITVIYTINN QLRGVDPLFN VTIEVSVKSG SVLLAVLEEA QRKNSMFKFE TTMTSWGLIV SSINNIAENV NHKTYWEFLS GKTPLDEGVA YYIPFNHEHI TANFTQY //