ID YFHK_ECOLI Reviewed; 475 AA. AC P52101; P76587; Q2MAH4; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 15-JAN-2008, sequence version 3. DT 19-JAN-2010, entry version 87. DE RecName: Full=Putative sensor-like histidine kinase yfhK; DE EC=2.7.13.3; DE Flags: Precursor; GN Name=yfhK; OrderedLocusNames=b2556, JW5407; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [3] RP TOPOLOGY [LARGE SCALE ANALYSIS]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=15919996; DOI=10.1126/science.1109730; RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.; RT "Global topology analysis of the Escherichia coli inner membrane RT proteome."; RL Science 308:1321-1323(2005). CC -!- FUNCTION: Probable member of a two-component regulatory system CC yfhA/yfhK. May activate yfhA by phosphorylation. CC -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N- CC phospho-L-histidine. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane CC protein. CC -!- SIMILARITY: Contains 1 histidine kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U36841; AAA79818.1; ALT_INIT; Genomic_DNA. DR EMBL; U00096; AAC75609.2; -; Genomic_DNA. DR EMBL; AP009048; BAE76732.1; -; Genomic_DNA. DR PIR; C65033; C65033. DR RefSeq; AP_003142.1; -. DR RefSeq; NP_417051.2; -. DR SMR; P52101; 86-133, 241-472. DR DIP; DIP-12052N; -. DR STRING; P52101; -. DR GeneID; 947013; -. DR GenomeReviews; AP009048_GR; JW5407. DR GenomeReviews; U00096_GR; b2556. DR KEGG; ecj:JW5407; -. DR KEGG; eco:b2556; -. DR EchoBASE; EB3234; -. DR EcoGene; EG13461; yfhK. DR eggNOG; COG0642; -. DR HOGENOM; HBG544172; -. DR OMA; CIEVANT; -. DR BioCyc; EcoCyc:G7345-MONOMER; -. DR BioCyc; ECOL168927:B2556-MONOMER; -. DR Genevestigator; P52101; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0000155; F:two-component sensor activity; IEA:InterPro. DR GO; GO:0018106; P:peptidyl-histidine phosphorylation; IEA:InterPro. DR GO; GO:0000160; P:two-component signal transduction system (p...; IEA:UniProtKB-KW. DR InterPro; IPR003594; ATPase-like_ATP-bd. DR InterPro; IPR003660; HAMP_linker_domain. DR InterPro; IPR004358; Sig_transdc_His_kin-like_C. DR InterPro; IPR003661; Sig_transdc_His_kin_sub1_dim/P. DR InterPro; IPR005467; Sig_transdc_His_kinase_core. DR InterPro; IPR009082; Sig_transdc_His_kinase_dimeric. DR Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1. DR Pfam; PF00672; HAMP; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF00512; HisKA; 1. DR PRINTS; PR00344; BCTRLSENSOR. DR SMART; SM00387; HATPase_c; 1. DR SMART; SM00388; HisKA; 1. DR PROSITE; PS50109; HIS_KIN; 1. PE 1: Evidence at protein level; KW ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; KW Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Signal; KW Transferase; Transmembrane; Two-component regulatory system. FT SIGNAL 1 30 Potential. FT CHAIN 31 475 Putative sensor-like histidine kinase FT yfhK. FT /FTId=PRO_0000074915. FT TRANSMEM 174 194 Potential. FT DOMAIN 256 472 Histidine kinase. FT MOD_RES 259 259 Phosphohistidine; by autocatalysis (By FT similarity). SQ SEQUENCE 475 AA; 53330 MW; EBB3F4D821C24AEB CRC64; MKRWPVFPRS LRQLVMLAFL LILLPLLVLA WQAWQSLNAL SDQAALVNRT TLIDARRSEA MTNAALEMER SYRQYCVLDD PTLAKVYQSQ RKRYSEMLDA HAGVLPDDKL YQALRQDLHN LAQLQCNNSG PDAAAAARLE AFASANTEMV QATRTVVFSR GQQLQREIAE RGQYFGWQSL VLFLVSLVMV LLFTRMIIGP VKNIERMINR LGEGRSLGNS VSFSGPSELR SVGQRILWLS ERLSWLESQR HQFLRHLSHE LKTPLASMRE GTELLADQVV GPLTPEQKEV VSILDSSSRN LQKLIEQLLD YNRKQADSAV ELENVELAPL VETVVSAHSL PARAKMMHTD VDLKATACLA EPMLLMSVLD NLYSNAVHYG AESGNICLRS SLHGARVYID VINTGTPIPQ EERAMIFEPF FQGSHQRKGA VKGSGLGLSI ARDCIRRMQG ELYLVDESGQ DVCFRIELPS SKNTK //