ID YFHK_ECOLI STANDARD; PRT; 496 AA. AC P52101; P76587; Q2MAH4; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 19-SEP-2006, entry version 53. DE Putative sensor-like histidine kinase yfhK (EC 2.7.13.3). GN Name=yfhK; OrderedLocusNames=b2556; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [3] RP TOPOLOGY. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=15919996; DOI=10.1126/science.1109730; RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.; RT "Global topology analysis of the Escherichia coli inner membrane RT proteome."; RL Science 308:1321-1323(2005). CC -!- FUNCTION: Probable member of a two-component regulatory system CC yfhA/yfhK. May activate yfhA by phosphorylation. CC -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N- CC phospho-L-histidine. CC -!- SUBCELLULAR LOCATION: Bacterial cell inner membrane; multi-pass CC membrane protein. CC -!- SIMILARITY: Contains 1 histidine kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U36841; AAA79818.1; ALT_INIT; Genomic_DNA. DR EMBL; U00096; AAC75609.1; -; Genomic_DNA. DR EMBL; AP009048; BAE76732.1; ALT_INIT; Genomic_DNA. DR PIR; C65033; C65033. DR GenomeReviews; U00096_GR; b2556. DR KEGG; eco:b2556; -. DR EchoBASE; EB3234; -. DR EcoGene; EG13214; yfhK. DR BioCyc; EcoCyc:G7345-MONOMER; -. DR InterPro; IPR003594; ATP_bd_ATPase. DR InterPro; IPR003660; His_kin_HAMP. DR InterPro; IPR009082; His_kin_homodim. DR InterPro; IPR004358; His_kin_like_C. DR InterPro; IPR003661; His_kinA_N. DR InterPro; IPR005467; His_kinase. DR Pfam; PF00672; HAMP; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF00512; HisKA; 1. DR PRINTS; PR00344; BCTRLSENSOR. DR SMART; SM00387; HATPase_c; 1. DR SMART; SM00388; HisKA; 1. DR PROSITE; PS50109; HIS_KIN; 1. KW Complete proteome; Inner membrane; Kinase; Membrane; Phosphorylation; KW Transferase; Transmembrane; Two-component regulatory system. FT CHAIN 1 496 Putative sensor-like histidine kinase FT yfhK. FT /FTId=PRO_0000074915. FT TOPO_DOM 1 34 Cytoplasmic (Potential). FT TRANSMEM 35 55 Potential. FT TOPO_DOM 56 194 Periplasmic (Potential). FT TRANSMEM 195 215 Potential. FT TOPO_DOM 216 496 Cytoplasmic (Potential). FT DOMAIN 277 493 Histidine kinase. FT MOD_RES 280 280 Phosphohistidine (by autocatalysis) (By FT similarity). SQ SEQUENCE 496 AA; 55699 MW; BAF13FF2C1027737 CRC64; MLYLNFPSVS IRLFASDESN TLKRWPVFPR SLRQLVMLAF LLILLPLLVL AWQAWQSLNA LSDQAALVNR TTLIDARRSE AMTNAALEME RSYRQYCVLD DPTLAKVYQS QRKRYSEMLD AHAGVLPDDK LYQALRQDLH NLAQLQCNNS GPDAAAAARL EAFASANTEM VQATRTVVFS RGQQLQREIA ERGQYFGWQS LVLFLVSLVM VLLFTRMIIG PVKNIERMIN RLGEGRSLGN SVSFSGPSEL RSVGQRILWL SERLSWLESQ RHQFLRHLSH ELKTPLASMR EGTELLADQV VGPLTPEQKE VVSILDSSSR NLQKLIEQLL DYNRKQADSA VELENVELAP LVETVVSAHS LPARAKMMHT DVDLKATACL AEPMLLMSVL DNLYSNAVHY GAESGNICLR SSLHGARVYI DVINTGTPIP QEERAMIFEP FFQGSHQRKG AVKGSGLGLS IARDCIRRMQ GELYLVDESG QDVCFRIELP SSKNTK //