ID YFHK_ECOLI STANDARD; PRT; 496 AA. AC P52101; P76587; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 07-FEB-2006, entry version 46. DE Putative sensor-like histidine kinase yfhK (EC 2.7.3.-). GN Name=yfhK; OrderedLocusNames=b2556; OS Escherichia coli. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [2] RP TOPOLOGY. RC STRAIN=K12 / MG1655; RX PubMed=15919996; DOI=10.1126/science.1109730; RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.; RT "Global topology analysis of the Escherichia coli inner membrane RT proteome."; RL Science 308:1321-1323(2005). CC -!- FUNCTION: Probable member of a two-component regulatory system CC yfhA/yfhK. May activate yfhA by phosphorylation. CC -!- SUBCELLULAR LOCATION: Inner membrane; multi-pass membrane protein. CC -!- SIMILARITY: Contains 1 histidine kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U36841; AAA79818.1; ALT_INIT; Genomic_DNA. DR EMBL; U00096; AAC75609.1; -; Genomic_DNA. DR PIR; C65033; C65033. DR EchoBASE; EB3234; -. DR EcoGene; EG13214; yfhK. DR BioCyc; EcoCyc:G7345-MONOMER; -. DR InterPro; IPR003594; ATP_bd_ATPase. DR InterPro; IPR003660; His_kin_HAMP. DR InterPro; IPR004358; His_kin_like_C. DR InterPro; IPR003661; His_kinA_N. DR InterPro; IPR005467; His_kinase. DR Pfam; PF00672; HAMP; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF00512; HisKA; 1. DR PRINTS; PR00344; BCTRLSENSOR. DR SMART; SM00387; HATPase_c; 1. DR SMART; SM00388; HisKA; 1. DR PROSITE; PS50109; HIS_KIN; 1. KW Complete proteome; Inner membrane; Kinase; Membrane; Phosphorylation; KW Sensory transduction; Transferase; Transmembrane; KW Two-component regulatory system. FT CHAIN 1 496 Putative sensor-like histidine kinase FT yfhK. FT /FTId=PRO_0000074915. FT TOPO_DOM 1 34 Cytoplasmic (Potential). FT TRANSMEM 35 55 Potential. FT TOPO_DOM 56 194 Periplasmic (Potential). FT TRANSMEM 195 215 Potential. FT TOPO_DOM 216 496 Cytoplasmic (Potential). FT DOMAIN 277 493 Histidine kinase. FT MOD_RES 280 280 Phosphohistidine (by autocatalysis) (By FT similarity). SQ SEQUENCE 496 AA; 55699 MW; BAF13FF2C1027737 CRC64; MLYLNFPSVS IRLFASDESN TLKRWPVFPR SLRQLVMLAF LLILLPLLVL AWQAWQSLNA LSDQAALVNR TTLIDARRSE AMTNAALEME RSYRQYCVLD DPTLAKVYQS QRKRYSEMLD AHAGVLPDDK LYQALRQDLH NLAQLQCNNS GPDAAAAARL EAFASANTEM VQATRTVVFS RGQQLQREIA ERGQYFGWQS LVLFLVSLVM VLLFTRMIIG PVKNIERMIN RLGEGRSLGN SVSFSGPSEL RSVGQRILWL SERLSWLESQ RHQFLRHLSH ELKTPLASMR EGTELLADQV VGPLTPEQKE VVSILDSSSR NLQKLIEQLL DYNRKQADSA VELENVELAP LVETVVSAHS LPARAKMMHT DVDLKATACL AEPMLLMSVL DNLYSNAVHY GAESGNICLR SSLHGARVYI DVINTGTPIP QEERAMIFEP FFQGSHQRKG AVKGSGLGLS IARDCIRRMQ GELYLVDESG QDVCFRIELP SSKNTK //