ID   ZN75D_HUMAN             Reviewed;         510 AA.
AC   P51815; A6NK62; B3KRI7; Q5JPG0; Q6LDE0;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   27-NOV-2024, entry version 203.
DE   RecName: Full=Zinc finger protein 75D;
DE   AltName: Full=Zinc finger protein 75;
DE   AltName: Full=Zinc finger protein 82;
GN   Name=ZNF75D; Synonyms=ZNF75, ZNF82;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 222-510.
RC   TISSUE=Lung fibroblast;
RX   PubMed=8288223; DOI=10.1006/geno.1993.1459;
RA   Villa A., Zucchi I., Pilia G., Strina D., Susani L., Morali F.,
RA   Patrosso C., Frattini A., Lucchini F., Repetto M., Sacco M.G., Zoppe M.,
RA   Vezzoni P.;
RT   "ZNF75: isolation of a cDNA clone of the KRAB zinc finger gene subfamily
RT   mapped in YACs 1 Mb telomeric of HPRT.";
RL   Genomics 18:223-229(1993).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-510.
RX   PubMed=1505955; DOI=10.1016/0888-7543(92)90040-y;
RA   Villa A., Patrosso C., Biunno I., Frattini A., Repetto M., Mostardini M.,
RA   Evans G., Susani L., Strina D., Redolfi E., Lazzari B., Pellegrini M.,
RA   Vezzoni P.;
RT   "Isolation of a zinc finger motif (ZNF75) mapping on chromosome Xq26.";
RL   Genomics 13:1231-1236(1992).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 360-510.
RA   Marino M., Archidiacono N., Franze N., Rosati M., Rocchi M., Ballabio A.,
RA   Grimaldi G.;
RT   "The human zinc finger gene family: isolation, mapping and expression of
RT   two X-linked members.";
RL   Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P51815-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P51815-2; Sequence=VSP_044460;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AK091687; BAG52399.1; -; mRNA.
DR   EMBL; AK290215; BAF82904.1; -; mRNA.
DR   EMBL; AL832801; CAI46130.1; -; mRNA.
DR   EMBL; AL450472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC109100; AAI09101.1; -; mRNA.
DR   EMBL; S67970; AAB29696.1; -; mRNA.
DR   EMBL; S43109; AAB22971.1; -; Genomic_DNA.
DR   EMBL; X68010; CAA48147.1; -; Genomic_DNA.
DR   CCDS; CCDS14648.1; -. [P51815-1]
DR   CCDS; CCDS55503.1; -. [P51815-2]
DR   PIR; A48913; A48913.
DR   RefSeq; NP_001171992.1; NM_001185063.2. [P51815-2]
DR   RefSeq; NP_009062.2; NM_007131.4. [P51815-1]
DR   RefSeq; XP_005262526.1; XM_005262469.1.
DR   RefSeq; XP_011529693.1; XM_011531391.1.
DR   AlphaFoldDB; P51815; -.
DR   SMR; P51815; -.
DR   BioGRID; 113445; 1.
DR   IntAct; P51815; 7.
DR   STRING; 9606.ENSP00000359802; -.
DR   iPTMnet; P51815; -.
DR   PhosphoSitePlus; P51815; -.
DR   BioMuta; ZNF75D; -.
DR   DMDM; 212276486; -.
DR   jPOST; P51815; -.
DR   MassIVE; P51815; -.
DR   PaxDb; 9606-ENSP00000359802; -.
DR   PeptideAtlas; P51815; -.
DR   ProteomicsDB; 1382; -.
DR   ProteomicsDB; 56418; -. [P51815-1]
DR   Antibodypedia; 846; 109 antibodies from 25 providers.
DR   DNASU; 7626; -.
DR   Ensembl; ENST00000370764.1; ENSP00000359800.1; ENSG00000186376.15. [P51815-2]
DR   Ensembl; ENST00000370766.8; ENSP00000359802.3; ENSG00000186376.15. [P51815-1]
DR   GeneID; 7626; -.
DR   KEGG; hsa:7626; -.
DR   MANE-Select; ENST00000370766.8; ENSP00000359802.3; NM_007131.5; NP_009062.2.
DR   UCSC; uc004eyo.5; human. [P51815-1]
DR   AGR; HGNC:13145; -.
DR   CTD; 7626; -.
DR   DisGeNET; 7626; -.
DR   GeneCards; ZNF75D; -.
DR   HGNC; HGNC:13145; ZNF75D.
DR   HPA; ENSG00000186376; Low tissue specificity.
DR   MIM; 314997; gene.
DR   neXtProt; NX_P51815; -.
DR   OpenTargets; ENSG00000186376; -.
DR   PharmGKB; PA37719; -.
DR   VEuPathDB; HostDB:ENSG00000186376; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162817; -.
DR   HOGENOM; CLU_002678_49_4_1; -.
DR   InParanoid; P51815; -.
DR   OMA; FNYHEAP; -.
DR   OrthoDB; 2315530at2759; -.
DR   PhylomeDB; P51815; -.
DR   TreeFam; TF341729; -.
DR   PathwayCommons; P51815; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; P51815; -.
DR   BioGRID-ORCS; 7626; 5 hits in 800 CRISPR screens.
DR   ChiTaRS; ZNF75D; human.
DR   GenomeRNAi; 7626; -.
DR   Pharos; P51815; Tdark.
DR   PRO; PR:P51815; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; P51815; protein.
DR   Bgee; ENSG00000186376; Expressed in primordial germ cell in gonad and 149 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   CDD; cd07936; SCAN; 1.
DR   FunFam; 3.30.160.60:FF:000720; zinc finger protein 18 isoform X2; 1.
DR   FunFam; 1.10.4020.10:FF:000001; zinc finger protein 263 isoform X1; 1.
DR   FunFam; 3.30.160.60:FF:000212; zinc finger protein 382 isoform X2; 2.
DR   FunFam; 3.30.160.60:FF:001261; Zinc finger protein 75a; 1.
DR   FunFam; 3.30.160.60:FF:001340; zinc finger protein 75D isoform X1; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR   Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR050169; Krueppel_C2H2_ZnF.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR   PANTHER; PTHR23232:SF143; ZINC FINGER PROTEIN 747; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..510
FT                   /note="Zinc finger protein 75D"
FT                   /id="PRO_0000047384"
FT   DOMAIN          49..131
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   DOMAIN          235..318
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         365..387
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         393..415
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         421..443
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         449..471
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         477..499
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         138..232
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_044460"
FT   CONFLICT        409
FT                   /note="N -> S (in Ref. 1; BAG52399)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   510 AA;  59298 MW;  37D405F102965A24 CRC64;
     MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR HFWSFRYHEA
     TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI LPKETQNWVQ KHHPQNVKQA
     LVLVEFLQRE PDGTKNEVTA HELGKEAVLL GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY
     RVLQEQLGWN THKETQPVYE RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV
     AVYFSEEEWQ LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC
     EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK LMDLHGKGPT
     GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR RFRWSSDLNK HFMTHQGIKP
     YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS
     LCKRNFSRRS SLLRHQKLHR RREACLVSPN
//