ID   ZNF80_HUMAN             Reviewed;         273 AA.
AC   P51504; Q6NSW4; Q6NT14;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 2.
DT   03-MAY-2023, entry version 182.
DE   RecName: Full=Zinc finger protein 80;
DE   AltName: Full=ZNFpT17;
GN   Name=ZNF80;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8478004; DOI=10.1007/bf00218259;
RA   Huebner K., Druck T., LaForgia S., Lasota J., Croce C.M., Lanfrancone L.,
RA   Donti E., Pengue G., la Mantia G., Pelicci P.-G., Lania L.;
RT   "Chromosomal localization of four human zinc finger cDNAs.";
RL   Hum. Genet. 91:217-222(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7659503; DOI=10.1093/nar/23.15.2823;
RA   di Cristofano A., Strazzullo M., Longo L., la Mantia G.;
RT   "Characterization and genomic mapping of the ZNF80 locus: expression of
RT   this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous
RT   retroviral family.";
RL   Nucleic Acids Res. 23:2823-2830(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       P51504; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-12013828, EBI-739580;
CC       P51504; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12013828, EBI-3866279;
CC       P51504; Q86X02: CDR2L; NbExp=3; IntAct=EBI-12013828, EBI-11063830;
CC       P51504; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-12013828, EBI-5916454;
CC       P51504; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-12013828, EBI-746704;
CC       P51504; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-12013828, EBI-3044087;
CC       P51504; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-12013828, EBI-10172052;
CC       P51504; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12013828, EBI-11953334;
CC       P51504; Q2NL98: VMAC; NbExp=3; IntAct=EBI-12013828, EBI-2803134;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; X65233; CAA46340.1; -; mRNA.
DR   EMBL; CH471052; EAW79603.1; -; Genomic_DNA.
DR   EMBL; BC069606; AAH69606.2; -; mRNA.
DR   EMBL; BC069826; AAH69826.2; -; mRNA.
DR   EMBL; BC129925; AAI29926.1; -; mRNA.
DR   CCDS; CCDS2979.1; -.
DR   RefSeq; NP_009067.2; NM_007136.3.
DR   RefSeq; XP_016862621.1; XM_017007132.1.
DR   RefSeq; XP_016862622.1; XM_017007133.1.
DR   RefSeq; XP_016862623.1; XM_017007134.1.
DR   RefSeq; XP_016862624.1; XM_017007135.1.
DR   RefSeq; XP_016862625.1; XM_017007136.1.
DR   AlphaFoldDB; P51504; -.
DR   SMR; P51504; -.
DR   BioGRID; 113452; 10.
DR   IntAct; P51504; 9.
DR   STRING; 9606.ENSP00000417192; -.
DR   GlyGen; P51504; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P51504; -.
DR   PhosphoSitePlus; P51504; -.
DR   BioMuta; ZNF80; -.
DR   DMDM; 206729946; -.
DR   MassIVE; P51504; -.
DR   MaxQB; P51504; -.
DR   PaxDb; P51504; -.
DR   PeptideAtlas; P51504; -.
DR   ProteomicsDB; 56310; -.
DR   Antibodypedia; 32644; 23 antibodies from 12 providers.
DR   DNASU; 7634; -.
DR   Ensembl; ENST00000308095.4; ENSP00000309812.4; ENSG00000174255.8.
DR   Ensembl; ENST00000482457.4; ENSP00000417192.3; ENSG00000174255.8.
DR   GeneID; 7634; -.
DR   KEGG; hsa:7634; -.
DR   MANE-Select; ENST00000482457.4; ENSP00000417192.3; NM_007136.4; NP_009067.2.
DR   UCSC; uc010hqo.5; human.
DR   AGR; HGNC:13155; -.
DR   CTD; 7634; -.
DR   DisGeNET; 7634; -.
DR   GeneCards; ZNF80; -.
DR   HGNC; HGNC:13155; ZNF80.
DR   HPA; ENSG00000174255; Tissue enriched (lymphoid).
DR   MIM; 194553; gene.
DR   neXtProt; NX_P51504; -.
DR   OpenTargets; ENSG00000174255; -.
DR   PharmGKB; PA37729; -.
DR   VEuPathDB; HostDB:ENSG00000174255; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000164925; -.
DR   HOGENOM; CLU_002678_2_1_1; -.
DR   InParanoid; P51504; -.
DR   OMA; YHSVFFR; -.
DR   OrthoDB; 4124602at2759; -.
DR   PhylomeDB; P51504; -.
DR   TreeFam; TF337055; -.
DR   PathwayCommons; P51504; -.
DR   SignaLink; P51504; -.
DR   BioGRID-ORCS; 7634; 14 hits in 1173 CRISPR screens.
DR   GenomeRNAi; 7634; -.
DR   Pharos; P51504; Tdark.
DR   PRO; PR:P51504; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P51504; protein.
DR   Bgee; ENSG00000174255; Expressed in granulocyte and 52 other tissues.
DR   Genevisible; P51504; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR23226:SF203; ZINC FINGER PROTEIN 80; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..273
FT                   /note="Zinc finger protein 80"
FT                   /id="PRO_0000047391"
FT   ZN_FING         49..71
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         77..99
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         105..127
FT                   /note="C2H2-type 3; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         133..155
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         161..183
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         189..211
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         217..239
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         201
FT                   /note="R -> H (in dbSNP:rs6438191)"
FT                   /id="VAR_046561"
FT   VARIANT         253
FT                   /note="D -> A (in dbSNP:rs3732782)"
FT                   /id="VAR_019972"
FT   CONFLICT        95
FT                   /note="P -> H (in Ref. 1; CAA46340)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  31224 MW;  16A1CA82DCE2F579 CRC64;
     MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK CKECGSVFNK
     NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT GEKPCKCVEC GKVFNRRSHL
     LCYRQIHTGE KPYECSECGK TFSYHSVFIQ HRVTHTGEKL FGCKECGKTF YYNSSLTRHM
     KIHTGEKPCK CSECGKTFTY RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT
     GEKPYECLEH RKDFGYHSAF AQQSKIHSGG KNL
//