ID CADH_EUCBO STANDARD; PRT; 355 AA. AC P50746; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Cinnamyl alcohol dehydrogenase (EC 1.1.1.195) (CAD). GN Name=CAD1; OS Eucalyptus botryoides. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids; OC Myrtales; Myrtaceae; Eucalyptus. OX NCBI_TaxID=33130; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Callus; RX MEDLINE=94159802; PubMed=7906894; RA Hibino T., Chen J.-Q., Shibata D., Higuchi T.; RT "Nucleotide sequence of a Eucalyptus botryoides gene encoding cinnamyl RT alcohol dehydrogenase."; RL Plant Physiol. 104:305-306(1994). CC -!- FUNCTION: This protein catalyzes the final step in a branch of CC phenylpropanoid synthesis specific for production of lignin CC monomers. It acts on coniferyl-, sinapyl-, 4-coumaryl- and CC cinnamyl-alcohol. CC -!- CATALYTIC ACTIVITY: Cinnamyl alcohol + NADP(+) = cinnamaldehyde + CC NADPH. CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity). CC -!- PATHWAY: Lignin biosynthesis. CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16624; BAA04046.1; ALT_SEQ. DR InterPro; IPR002328; ADH_zinc. DR InterPro; IPR002085; Adh_zn_family. DR InterPro; IPR011032; GroES_like. DR Pfam; PF00107; ADH_zinc_N; 1. DR PROSITE; PS00059; ADH_ZINC; 1. KW Oxidoreductase; Zinc; Metal-binding; NADP; Lignin biosynthesis. FT METAL 47 47 Zinc 1 (catalytic) (By similarity). FT METAL 69 69 Zinc 1 (catalytic) (By similarity). FT METAL 100 100 Zinc 2 (By similarity). FT METAL 103 103 Zinc 2 (By similarity). FT METAL 106 106 Zinc 2 (By similarity). FT METAL 114 114 Zinc 2 (By similarity). FT METAL 162 162 Zinc 1 (catalytic) (By similarity). SQ SEQUENCE 355 AA; 38679 MW; 8F1D067A409D629A CRC64; MGSLEKERTT TGWAARDPSG VLSPYTYSLR NTGPEDLYIK VLSCGICHSD IHQIKNDLGM SHYPMVPGHE VVGEVLEVGS EVTKYRVGDR VGTGIVVGCC RSCGPCNSDQ EQYCNKKIWN YNDVYTDGKP TQGGFAGEIV VGQRFVVKIP DGLESEQDAV MCAGVTVYSP LVRFGLKQSG LRGGILGLGG VGHMGVKIAK AMGHHVTVIS SSDKKRTEAL EHLGADAYLV SSDENGMKEA TDSLDYIFDT IPVVHPLEPY LALLKLDGKL ILTGVINAPL QFISPMVMLG RKSITGSFIG SMKETEEMLE FCKEKGLTSQ IEVIKMDYVN TALERLEKND VRYRFVVDVA GSKLD //