ID ERF_HUMAN STANDARD; PRT; 548 AA. AC P50548; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE ETS-RELATED PROTEIN ERF. GN ERF. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 96030784. RA SGOURAS D.N., ATHANASIOU M.A., BEAL G.J. JR., FISHER R.J., BLAIR D.G., RA MAVROTHALASSITIS G.J.; RL EMBO J. 14:4781-4793(1995). CC -!- FUNCTION: POTENT TRANSCRIPTIONAL REPRESSOR THAT BINDS TO THE H1 CC ELEMENT OF THE ETS2 PROMOTER. MAY REGULATE OTHER GENES INVOLVED CC IN CELLULAR PROLIFERATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- PTM: PHOSPHORYLATED BY MULTIPLE KINASES INCLUDING PROBABLY ERK2. CC PHOSPHORYLATION REGULATES THE ACTIVITY OF ERF. CC -!- SIMILARITY: REGIONS OF SIMILARITIES WITH OTHER ETS FAMILY CC PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U15655; G1015337; -. DR PROSITE; PS00345; ETS_DOMAIN_1; 1. DR PROSITE; PS00346; ETS_DOMAIN_2; 1. DR PROSITE; PS50061; ETS_DOMAIN_3; 1. KW TRANSCRIPTION REGULATION; REPRESSOR; DNA-BINDING; NUCLEAR PROTEIN; KW PHOSPHORYLATION. FT DNA_BIND 27 107 ETS-DOMAIN. FT DOMAIN 166 171 POLY-SER. FT DOMAIN 290 293 POLY-GLY. FT DOMAIN 362 373 POLY-SER. FT DOMAIN 418 423 POLY-PRO. FT DOMAIN 496 499 POLY-GLY. FT MOD_RES 526 526 PHOSPHORYLATION (BY ERK2). FT MUTAGEN 526 526 T->A: LOSS OF A PHOSPHORYLATION SITE. SQ SEQUENCE 548 AA; 58776 MW; 971D7F6D CRC32; MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG DYGEFVIKDP DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK RFTYKFNFNK LVLVNYPFID VGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS EVLSPTEDPR SPPACSSSSS SLFSAVVARR LGRGSVSDCS DGTSELEEPL GEDPRARPPG PPDLGAFRGP PLARLPHDPG VFRVYPRPRG GPEPLSPFPV SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL PPMAPETPPV PSSASSSSSS SSSPFKFKLQ RPPLGRRQRA AGEKAVAAAD KSGGSAGGLA EGAGALAPPP PPPQIKVEPI SEGESEEVEV TDISDEDEED GEVFKTPRAP PAPPKPEPGE APGASQCMPL KLRFKRRWSE DCRLEGGGGP AGGFEDEGED KKVRGEGPGE AGGPLTPRRV SSDLQHATAQ LSLEHRDS //