ID SPS1_HUMAN STANDARD; PRT; 383 AA. AC P49903; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE SELENIDE,WATER DIKINASE 1 (EC 2.7.9.3) (SELENOPHOSPHATE SYNTHETASE 1) DE (SELENIUM DONOR PROTEIN 1). GN SPS OR SPS1 OR SELD. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER; RX MEDLINE=95394923; PubMed=7665581; RA Low S.C., Harney J.W., Berry M.J.; RT "Cloning and functional characterization of human selenophosphate RT synthetase, an essential component of selenoprotein synthesis."; RL J. Biol. Chem. 270:21659-21664(1995). CC -!- FUNCTION: SYNTHESIZES SELENOPHOSPHATE FROM SELENIDE AND ATP. CC -!- CATALYTIC ACTIVITY: ATP + SELENIDE + H(2)O = AMP + SELENOPHOSPHATE CC + PHOSPHATE. CC -!- SIMILARITY: BELONGS TO THE SELENOPHOSPHATE SYNTHETASE 1 FAMILY. CC CLASS II SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34044; AAA87567.1; -. DR MIM; 600902; -. DR INTERPRO; IPR000728; -. DR PFAM; PF00586; AIRS; 1. KW Transferase; Selenium; ATP-binding. FT ACT_SITE 31 31 POTENTIAL. FT SITE 32 32 IMPORTANT FOR CATALYTIC ACTIVITY (BY FT SIMILARITY). FT NP_BIND 268 274 ATP (POTENTIAL). FT MUTAGEN 268 268 G->C: NO CHANGE IN ATP-BINDING. FT MUTAGEN 270 270 G->R: NO CHANGE IN ATP-BINDING. FT MUTAGEN 273 273 G->A,D,V: LOSS OF ATP-BINDING. FT MUTAGEN 274 274 H->N: REDUCED ATP-BINDING. FT MUTAGEN 274 274 H->Y: INCREASED ATP-BINDING. SQ SEQUENCE 383 AA; 42268 MW; CFD386C4C8AA5309 CRC64; MSTRESFNPE SYELDKSFRL TRFTELKGTG CKVPQDVLQK LLESLQENHF QEDEQFLGAV MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD NMLMLLGVSN KMTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWI VLGGVATTVC QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA MMNMARLNRT AAGLMHTFNT HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG NRTARIIDKP RIIEVAHKWP LKT //