ID SELD_HUMAN STANDARD; PRT; 383 AA. AC P49903; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE SELENIDE,WATER DIKINASE (EC 2.7.9.3) (SELENOPHOSPHATE SYNTHETASE) DE (SELENIUM DONOR PROTEIN). GN SELD. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER; RX MEDLINE; 95394923. RA LOW S.C., HARNEY J.W., BERRY M.J.; RL J. BIOL. CHEM. 270:21659-21664(1995). CC -!- FUNCTION: SYNTHESIZES SELENOPHOSPHATE FROM SELENIDE AND ATP. CC -!- CATALYTIC ACTIVITY: ATP + SELENIDE + H(2)O = AMP + SELENOPHOSPHATE CC + PHOSPHATE. CC -!- SIMILARITY: TO BACTERIAL SELD. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U34044; G1000284; -. DR MIM; 600902; -. KW TRANSFERASE; SELENIUM; ATP-BINDING. FT ACT_SITE 31 31 POTENTIAL. FT NP_BIND 268 274 ATP (POTENTIAL). FT MUTAGEN 268 268 G->C: NO CHANGE IN ATP-BINDING. FT MUTAGEN 270 270 G->R: NO CHANGE IN ATP-BINDING. FT MUTAGEN 273 273 G->A,D,V: LOSS OF ATP-BINDING. FT MUTAGEN 274 274 H->N: REDUCED ATP-BINDING. FT MUTAGEN 274 274 H->Y: INCREASED ATP-BINDING. SQ SEQUENCE 383 AA; 42268 MW; 3AF1A4A8 CRC32; MSTRESFNPE SYELDKSFRL TRFTELKGTG CKVPQDVLQK LLESLQENHF QEDEQFLGAV MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD NMLMLLGVSN KMTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWI VLGGVATTVC QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA MMNMARLNRT AAGLMHTFNT HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA AVSKACGNMF GLMHGTCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG NRTARIIDKP RIIEVAHKWP LKT //