ID CLK1_HUMAN STANDARD; PRT; 484 AA. AC P49759; DT 01-OCT-1996 (REL. 34, CREATED) DT 01-OCT-1996 (REL. 34, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE PROTEIN KINASE CLK1 (EC 2.7.1.-) (CLK). GN CLK OR CLK1. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91139618. RA JOHNSON K.W., SMITH K.A.; RL J. BIOL. CHEM. 266:3402-3407(1991). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 95082033. RA HANES J.J., DER KAMMER H., KLAUDINY J.J., SCHEIT K.H.; RL J. MOL. BIOL. 244:665-672(1994). CC -!- FUNCTION: PHOSPHORYLATES SERINES, THREONINES AND TYROSINES. CC PHOSPHORYLATES SR FAMILY OF SPLICING FACTORS. SEEMS TO DIRECTLY CC REGULATES THE ACTIVITY AND COMPARTIMENTALIZATION OF SR SPLICING CC FACTORS (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- PTM: AUTOPHOSPHORYLATES ON ALL THREE TYPE OF RESIDUES (BY CC SIMILARITY). CC -!- ALTERNATIVE PRODUCTS: TWO FORMS ARE PRODUCED BY ALTERNATIVE CC SPLICING, THE SHORTEST FORM LACK THE KINASE DOMAIN. CC -!- SIMILARITY: WITH THE CONSERVED CATALYTIC DOMAINS OF SER/THR- CC PROTEIN KINASES. BELONGS TO THE LAMMER SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L29219; G632964; -. DR EMBL; L29222; G632962; -. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. KW TRANSFERASE; SERINE/THREONINE-PROTEIN KINASE; ATP-BINDING; KW TYROSINE-PROTEIN KINASE; PHOSPHORYLATION; NUCLEAR PROTEIN; KW ALTERNATIVE SPLICING. FT DOMAIN 161 477 PROTEIN KINASE. FT NP_BIND 167 175 ATP (BY SIMILARITY). FT BINDING 191 191 ATP (BY SIMILARITY). FT ACT_SITE 288 288 BY SIMILARITY. FT VARSPLIC 131 136 KSHRRK -> MKLLIL (IN SHORT FORM). FT VARSPLIC 137 484 MISSING (IN SHORT FORM). SQ SEQUENCE 484 AA; 57205 MW; 99B67338 CRC32; MRHSKRTYCP DWDDKDWDYG KWRSSSSHKR RKRSHSSAQE NKRCKYNHSK MCDSHYLESR SINEKDYHSR RYIDEYRNDY TQGCEPGHRQ RDHESRYQNH SSKSSGRSGR SSYKSKHRIH HSTSHRRSHG KSHRRKRTRS VEDDEEGHLI CQSGDVLSAR YEIVDTLGEG AFGKVVECID HKAGGRHVAV KIVKNVDRYC EAARSEIQVL EHLNTTDPNS TFRCVQMLEW FEHHGHICIV FELLGLSTYD FIKENGFLPF RLDHIRKMAY QICKSVNFLH SNKLTHTDLK PENILFVQSD YTEAYNPKIK RDERTLINPD IKVVDFGSAT YDDEHHSTLV STRHYRAPEV ILALGWSQPC DVWSIGCILI EYYLGFTVFP THDSKEHLAM MERILGPLPK HMIQKTRKRK YFHHDRLDWD EHSSAGRYVS RACKPLKEFM LSQDVEHERL FDLIQKMLEY DPAKRITLRE ALKHPFFDLL KKSI //