ID   GPR15_HUMAN             Reviewed;         360 AA.
AC   P49685; Q3MIL4; Q6ISN6;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   10-FEB-2021, entry version 158.
DE   RecName: Full=G-protein coupled receptor 15;
DE   AltName: Full=Brother of Bonzo;
DE            Short=BoB;
GN   Name=GPR15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8838812; DOI=10.1006/geno.1996.0143;
RA   Heiber M., Marchese A., Nguyen T., Heng H.H.Q., George S.R., O'Dowd B.F.;
RT   "A novel human gene encoding a G-protein-coupled receptor (GPR15) is
RT   located on chromosome 3.";
RL   Genomics 32:462-465(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable chemokine receptor. Alternative coreceptor with CD4
CC       for HIV-1 infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U34806; AAC50826.1; -; Genomic_DNA.
DR   EMBL; BC069437; AAH69437.1; -; mRNA.
DR   EMBL; BC101779; AAI01780.1; -; mRNA.
DR   EMBL; BC101781; AAI01782.1; -; mRNA.
DR   CCDS; CCDS2931.1; -.
DR   PIR; G02064; G02064.
DR   RefSeq; NP_005281.1; NM_005290.3.
DR   BioGRID; 109098; 2.
DR   ELM; P49685; -.
DR   STRING; 9606.ENSP00000284311; -.
DR   GuidetoPHARMACOLOGY; 87; -.
DR   iPTMnet; P49685; -.
DR   PhosphoSitePlus; P49685; -.
DR   BioMuta; GPR15; -.
DR   DMDM; 1346170; -.
DR   jPOST; P49685; -.
DR   MassIVE; P49685; -.
DR   PaxDb; P49685; -.
DR   PeptideAtlas; P49685; -.
DR   PRIDE; P49685; -.
DR   ProteomicsDB; 56051; -.
DR   Antibodypedia; 2944; 374 antibodies.
DR   DNASU; 2838; -.
DR   Ensembl; ENST00000284311; ENSP00000284311; ENSG00000154165.
DR   GeneID; 2838; -.
DR   KEGG; hsa:2838; -.
DR   UCSC; uc011bgy.3; human.
DR   CTD; 2838; -.
DR   DisGeNET; 2838; -.
DR   GeneCards; GPR15; -.
DR   HGNC; HGNC:4469; GPR15.
DR   HPA; ENSG00000154165; Group enriched (blood, intestine, lymphoid tissue, urinary bladder).
DR   MIM; 601166; gene.
DR   neXtProt; NX_P49685; -.
DR   OpenTargets; ENSG00000154165; -.
DR   PharmGKB; PA28858; -.
DR   VEuPathDB; HostDB:ENSG00000154165.4; -.
DR   eggNOG; ENOG502RCE3; Eukaryota.
DR   GeneTree; ENSGT01010000222307; -.
DR   HOGENOM; CLU_009579_8_1_1; -.
DR   InParanoid; P49685; -.
DR   OMA; CCITRKL; -.
DR   OrthoDB; 1201347at2759; -.
DR   PhylomeDB; P49685; -.
DR   TreeFam; TF330024; -.
DR   PathwayCommons; P49685; -.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR   BioGRID-ORCS; 2838; 3 hits in 869 CRISPR screens.
DR   GeneWiki; GPR15; -.
DR   GenomeRNAi; 2838; -.
DR   Pharos; P49685; Tbio.
DR   PRO; PR:P49685; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P49685; protein.
DR   Bgee; ENSG00000154165; Expressed in rectum and 85 other tissues.
DR   ExpressionAtlas; P49685; baseline and differential.
DR   Genevisible; P49685; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0015026; F:coreceptor activity; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR   GO; GO:0001618; F:virus receptor activity; IDA:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0072678; P:T cell migration; IEA:Ensembl.
DR   GO; GO:0046718; P:viral entry into host cell; IDA:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..360
FT                   /note="G-protein coupled receptor 15"
FT                   /id="PRO_0000069531"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..69
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         37
FT                   /note="P -> S (in dbSNP:rs2230344)"
FT                   /id="VAR_020075"
FT   VARIANT         112
FT                   /note="M -> V (in dbSNP:rs35320046)"
FT                   /id="VAR_049391"
SQ   SEQUENCE   360 AA;  40787 MW;  F781F28B7E312390 CRC64;
     MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
     KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
     VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
     PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI
     KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
     IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL
//