ID   CXCR3_HUMAN             Reviewed;         368 AA.
AC   P49682; O15185; Q7Z710; Q9P2T4; Q9P2T5;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   20-FEB-2007, entry version 69.
DE   C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (Interferon-
DE   inducible protein 10 receptor) (IP-10 receptor) (CKR-L2) (CD183
DE   antigen) (G protein-coupled receptor 9).
GN   Name=CXCR3; Synonyms=GPR9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Blood;
RX   MEDLINE=97188912; PubMed=9064356; DOI=10.1084/jem.184.3.963;
RA   Loetscher M., Gerber B., Loetscher P., Jones S.A., Piali L.,
RA   Clark-Lewis I., Baggiolini M., Moser B.;
RT   "Chemokine receptor specific for IP10 and mig: structure, function,
RT   and expression in activated T-lymphocytes.";
RL   J. Exp. Med. 184:963-969(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND TISSUE
RP   SPECIFICITY.
RX   MEDLINE=22666871; PubMed=12782716; DOI=10.1084/jem.20021897;
RA   Lasagni L., Francalanci M., Annunziato F., Lazzeri E., Giannini S.,
RA   Cosmi L., Sagrinati C., Mazzinghi B., Orlando C., Maggi E., Marra F.,
RA   Romagnani S., Serio M., Romagnani P.;
RT   "An alternatively spliced variant of CXCR3 mediates the inhibition of
RT   endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as
RT   functional receptor for platelet factor 4.";
RL   J. Exp. Med. 197:1537-1549(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA   Gutierrez J., Varona R., Zaballos A., Lind P., Marquez G.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Leukocyte;
RA   Warren C.N., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction
RT   sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, Lung, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-368.
RX   MEDLINE=96115583; PubMed=8666380;
RA   Marchese A., Heiber M., Nguyen T., Heng H.H.Q., Saldivia V.R.,
RA   Cheng R., Murphy P.M., Tsui L.-C., Shi X., Gregor P., George S.R.,
RA   O'Dowd B.F., Docherty J.M.;
RT   "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
RT   and GPR14, encoding receptors related to interleukin 8, neuropeptide
RT   Y, and somatostatin receptors.";
RL   Genomics 29:335-344(1995).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 278-368, AND VARIANTS GLN-292 AND
RP   THR-363.
RX   MEDLINE=21040285; PubMed=11196695; DOI=10.1038/sj.gene.6363682;
RA   Kato H., Tsuchiya N., Tokunaga K.;
RT   "Single nucleotide polymorphisms in the coding regions of human CXC-
RT   chemokine receptors CXCR1, CXCR2 and CXCR3.";
RL   Genes Immun. 1:330-337(2000).
RN   [8]
RP   ALTERNATIVE SPLICING (ISOFORM 3), AND FUNCTION.
RX   PubMed=15528361;
RA   Ehlert J.E., Addison C.A., Burdick M.D., Kunkel S.L., Strieter R.M.;
RT   "Identification and partial characterization of a variant of human
RT   CXCR3 generated by posttranscriptional exon skipping.";
RL   J. Immunol. 173:6234-6240(2004).
RN   [9]
RP   LIGAND-BINDING.
RC   TISSUE=Fetal astrocyte;
RX   MEDLINE=98290735; PubMed=9625760; DOI=10.1084/jem.187.12.2009;
RA   Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M.,
RA   Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G.,
RA   Neote K.;
RT   "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel
RT   non-ELR CXC chemokine with potent activity on activated T cells
RT   through selective high affinity binding to CXCR3.";
RL   J. Exp. Med. 187:2009-2021(1998).
CC   -!- FUNCTION: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the
CC       proliferation of human mesangial cells (HMC). Isoform 2 is a
CC       receptor for CXCL4 and also mediates the inhibitory activities of
CC       CXCL9, CXCL10 and CXCL11 on the growth of human microvascular
CC       endothelial cells (HMVEC). Isoform 2 may play a role in
CC       angiogenesis. Isoform 3 mediates activity of CXCL11.
CC   -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=CXCR3-A;
CC         IsoId=P49682-1; Sequence=Displayed;
CC       Name=2; Synonyms=CXCR3-B;
CC         IsoId=P49682-2; Sequence=VSP_015684;
CC       Name=3; Synonyms=CXCR3-alt;
CC         IsoId=P49682-3; Sequence=VSP_015685;
CC         Note=Due to exon skipping;
CC   -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed
CC       in heart, kidney, liver and skeletal muscle. Isoform 1 is also
CC       expressed in placenta.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR   EMBL; X95876; CAA65126.1; -; mRNA.
DR   EMBL; AF469635; AAP55851.1; -; mRNA.
DR   EMBL; Z79783; CAB02143.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AY242128; AAO92295.1; -; mRNA.
DR   EMBL; BC034403; AAH34403.1; -; mRNA.
DR   EMBL; U32674; AAC50505.1; -; Genomic_DNA.
DR   EMBL; AB032735; BAA92297.1; -; Genomic_DNA.
DR   EMBL; AB032736; BAA92298.1; -; Genomic_DNA.
DR   UniGene; Hs.198252; -.
DR   DIP; DIP:5891N; -.
DR   Ensembl; ENSG00000186810; Homo sapiens.
DR   KEGG; hsa:2833; -.
DR   H-InvDB; HIX0016864; -.
DR   HGNC; HGNC:4540; CXCR3.
DR   HPA; HPA003189; -.
DR   MIM; 300574; gene.
DR   ArrayExpress; P49682; -.
DR   GermOnline; ENSG00000186810; Homo sapiens.
DR   RZPD-ProtExp; N0043; -.
DR   RZPD-ProtExp; RZPDo834A0845; -.
DR   RZPD-ProtExp; RZPDo839F0661; -.
DR   RZPD-ProtExp; RZPDo839F0671; -.
DR   GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc.
DR   GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS:ProtInc.
DR   GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
DR   GO; GO:0006928; P:cell motility; TAS:ProtInc.
DR   GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR   GO; GO:0007204; P:elevation of cytosolic calcium ion concentr...; TAS:ProtInc.
DR   InterPro; IPR000355; Chmkine_rcpt.
DR   InterPro; IPR004070; CXC_3_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01532; CXCCHMKINER3.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
KW   Alternative splicing; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Polymorphism; Receptor; Transducer; Transmembrane.
FT   CHAIN         1    368       C-X-C chemokine receptor type 3.
FT                                /FTId=PRO_0000069346.
FT   TOPO_DOM      1     53       Extracellular (Potential).
FT   TRANSMEM     54     80       1 (Potential).
FT   TOPO_DOM     81     89       Cytoplasmic (Potential).
FT   TRANSMEM     90    110       2 (Potential).
FT   TOPO_DOM    111    125       Extracellular (Potential).
FT   TRANSMEM    126    147       3 (Potential).
FT   TOPO_DOM    148    169       Cytoplasmic (Potential).
FT   TRANSMEM    170    189       4 (Potential).
FT   TOPO_DOM    190    212       Extracellular (Potential).
FT   TRANSMEM    213    233       5 (Potential).
FT   TOPO_DOM    234    255       Cytoplasmic (Potential).
FT   TRANSMEM    256    277       6 (Potential).
FT   TOPO_DOM    278    298       Extracellular (Potential).
FT   TRANSMEM    299    321       7 (Potential).
FT   TOPO_DOM    322    368       Cytoplasmic (Potential).
FT   CARBOHYD     22     22       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     32     32       N-linked (GlcNAc...) (Potential).
FT   DISULFID    124    203       By similarity.
FT   VAR_SEQ       1      4       MVLE -> MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITK
FT                                EFLPGLYTAPSSPFPPSQ (in isoform 2).
FT                                /FTId=VSP_015684.
FT   VAR_SEQ     210    368       VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRR
FT                                LRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCG
FT                                RESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWML
FT                                LLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL -> G
FT                                SSSGSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRP
FT                                PTRACEAGIRAPLSPI (in isoform 3).
FT                                /FTId=VSP_015685.
FT   VARIANT     292    292       R -> Q.
FT                                /FTId=VAR_016240.
FT   VARIANT     363    363       A -> T.
FT                                /FTId=VAR_016241.
FT   CONFLICT     75     75       A -> R (in Ref. 3).
SQ   SEQUENCE   368 AA;  40660 MW;  F08A3B44B2BBAD04 CRC64;
     MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDRAFLPALY
     SLLFLLGLLG NGAVAAVLLS RRTALSSTDT FLLHLAVADT LLVLTLPLWA VDAAVQWVFG
     SGLCKVAGAL FNINFYAGAL LLACISFDRY LNIVHATQLY RRGPPARVTL TCLAVWGLCL
     LFALPDFIFL SAHHDERLNA THCQYNFPQV GRTALRVLQL VAGFLLPLLV MAYCYAHILA
     VLLVSRGQRR LRAMRLVVVV VVAFALCWTP YHLVVLVDIL MDLGALARNC GRESRVDVAK
     SVTSGLGYMH CCLNPLLYAF VGVKFRERMW MLLLRLGCPN QRGLQRQPSS SRRDSSWSET
     SEASYSGL
//