ID GR75_RAT STANDARD; PRT; 679 AA. AC P48721; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Stress-70 protein, mitochondrial precursor (75 kDa glucose regulated DE protein) (GRP 75) (Peptide-binding protein 74) (PBP74) (MTHSP70) DE (Mortalin). GN HSPA9 OR GRP75. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95110439; PubMed=7811387; RA Webster T.J., Naylor D.J., Hartman D.J., Hoej P.B., Hoogenraad N.J.; RT "cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from RT rat liver."; RL DNA Cell Biol. 13:1213-1220(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=95356254; PubMed=7629893; RA Massa S.M., Longo F.M., Zuo J., Wang S., Chen J., Sharp F.R.; RT "Cloning of rat grp75, an hsp70-family member, and its expression in RT normal and ischemic brain."; RL J. Neurosci. Res. 40:807-819(1995). CC -!- FUNCTION: IMPLICATED IN THE CONTROL OF CELL PROLIFERATION AND CC CELLULAR AGING. MAY ALSO ACT AS A CHAPERONE. CC -!- SUBCELLULAR LOCATION: Mitochondrial. CC -!- SIMILARITY: BELONGS TO THE HEAT SHOCK PROTEIN 70 FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S75280; AAB33049.1; -. DR EMBL; S78556; AAB34982.1; -. DR HSSP; P04475; 1DG4. DR InterPro; IPR001023; HSP70. DR Pfam; PF00012; HSP70; 1. DR PRINTS; PR00301; HEATSHOCK70. DR ProDom; PD000089; Hsp70; 1. DR PROSITE; PS00297; HSP70_1; 1. DR PROSITE; PS00329; HSP70_2; 1. DR PROSITE; PS01036; HSP70_3; 1. KW ATP-binding; Mitochondrion; Transit peptide. FT TRANSIT 1 46 MITOCHONDRION (BY SIMILARITY). FT CHAIN 47 679 STRESS-70 PROTEIN. FT CONFLICT 37 37 V -> A (IN REF. 2). FT CONFLICT 81 81 S -> A (IN REF. 2). FT CONFLICT 373 373 R -> A (IN REF. 2). FT CONFLICT 589 589 V -> I (IN REF. 2). SQ SEQUENCE 679 AA; 73859 MW; 85405F60EF1889C9 CRC64; MISASRAAAA RLVGTTASRS PAAARHQDGW NGLSHEVFRF VSRRDYASEA IKGAVVGIDL GTTNSCVAVM EGKQAKVLEN SEGARTTPSV VAFTPDGERL VGMPAKRQAV TNPNNTFYAT KRLIGRRYDD PEVQKDTKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDASGPK HLNMKLTRAQ FEGIVTDLIK RTIAPCQKAM QDREVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIVH DTETKMEEFK DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE GSGSSSTGEQ KEDQKEEKQ //