ID DPS1_PINST STANDARD; PRT; 396 AA. AC P48407; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Pinosylvin synthase 1 (EC 2.3.1.-) (Stilbene synthase 1) (STS 1). GN STS1. OS Pinus strobus (Eastern white pine). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Coniferopsida; Coniferales; Pinaceae; Pinus. OX NCBI_TaxID=3348; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95212569; PubMed=7698342; RA Raiber S., Schroeder G., Schroeder J.; RT "Molecular and enzymatic characterization of two stilbene synthases RT from Eastern white pine (Pinus strobus). A single Arg/His difference RT determines the activity and the pH dependence of the enzymes."; RL FEBS Lett. 361:299-302(1995). CC -!- FUNCTION: STS 1 has only 3-5% of the activity of STS 2, a lower CC optimal pH, and synthesizes a second unknown product with CC cinnamoyl-CoA. CC -!- CATALYTIC ACTIVITY: 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + CC pinosylvin + 3 CO(2). CC -!- PATHWAY: Stilbene-type phytoalexins biosynthesis. CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic. CC -!- INDUCTION: By stress. CC -!- SIMILARITY: Belongs to the chalcone/stilbene synthases family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z46914; CAA87012.1; -. DR PIR; S68772; S68772. DR HSSP; P30074; 1BI5. DR InterPro; IPR001099; N-C_synthase. DR Pfam; PF02797; Chal_sti_synt_C; 1. DR Pfam; PF00195; Chal_sti_synt_N; 1. DR PIRSF; PIRSF000451; PKS_III; 1. DR ProDom; PD000453; N-C_synthase; 1. DR PROSITE; PS00441; CHALCONE_SYNTH; 1. KW Transferase; Acyltransferase; Multigene family. FT ACT_SITE 170 170 By similarity. FT SITE 313 313 RESPONSIBLE FOR THE DIFFERENT ENZYMATIC FT PROPERTIES OF STS1 AND STS2. SQ SEQUENCE 396 AA; 43080 MW; A6ACF4F7B9FF11FA CRC64; MSVGMGIDLE AFRKSQRADG FASILAIGTA NPPNVVDQST YPDYYFRVTN NEDNTDLKDK FKRICERSAI KKRHMYLTEE ILKKNPELCA FLEVPSLDTR QAMLAAEVPR LGKEAAEKAI EEWGQPKSRI THLIFCTTTT PDLPGADFEV AKLLGLHPSV KRVGVFQHGC FAGGTVLRLA KDLAENNRGA RVLVVCSENT AVTFRGPSET HLDGLVGLAL FGDGASALIV GADPIPQVEK PCFEIVWTAQ TVVPNSDGAI SGKLREVGLT FQLKGAVPDL ISTNIEKCLV EAFSQFNISD WNQLFWIAHP GGHAILDQVE ASLNLDPTKL RATRHVMSEY GNMSSACVHF ILDETRKASR QNGCSTSGGG FQMGVLFGFG PGLTVETVVL KSIPFP //