ID   GLIP1_HUMAN             Reviewed;         266 AA.
AC   P48060; A7YET6; F8VUC2; Q15409; Q969K2;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2003, sequence version 3.
DT   12-AUG-2020, entry version 165.
DE   RecName: Full=Glioma pathogenesis-related protein 1;
DE            Short=GliPR 1;
DE   AltName: Full=Protein RTVP-1;
DE   Flags: Precursor;
GN   Name=GLIPR1; Synonyms=GLIPR, RTVP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=7607567; DOI=10.1016/0378-1119(95)00061-a;
RA   Murphy E.V., Zhang Y., Zhu W., Biggs J.;
RT   "The human glioma pathogenesis-related protein is structurally related to
RT   plant pathogenesis-related proteins and its gene is expressed specifically
RT   in brain tumors.";
RL   Gene 159:131-135(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   Murphy E.V.;
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Glial tumor;
RX   PubMed=8973356; DOI=10.1016/s0378-1119(96)00431-3;
RA   Rich T., Chen P., Furman F., Huynh N., Israel M.A.;
RT   "RTVP-1, a novel human gene with sequence similarity to genes of diverse
RT   species, is expressed in tumor cell lines of glial but not neuronal
RT   origin.";
RL   Gene 180:125-130(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Glial tumor;
RX   PubMed=17825796; DOI=10.1016/j.bbrc.2007.08.138;
RA   Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A.,
RA   Mikkelsen T., Brodie C.;
RT   "Cloning and characterization of human RTVP-1b, a novel splice variant of
RT   RTVP-1 in glioma cells.";
RL   Biochem. Biophys. Res. Commun. 362:612-618(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   STRUCTURE BY NMR.
RX   PubMed=9482873; DOI=10.1073/pnas.95.5.2262;
RA   Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K.;
RT   "Structure comparison of human glioma pathogenesis-related protein GliPR
RT   and the plant pathogenesis-related protein P14a indicates a functional link
RT   between the human immune system and a plant defense system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P48060-1; Sequence=Displayed;
CC       Name=2; Synonyms=RTVP-1b;
CC         IsoId=P48060-2; Sequence=VSP_043902;
CC   -!- TISSUE SPECIFICITY: According to PubMed:8973356, it is ubiquitously
CC       expressed with high levels in lung and kidney and low levels in heart
CC       and liver. Highly expressed in cell lines derived from nervous system
CC       tumors arising from glia, low or absent in non-glial-derived nervous
CC       system tumor cell lines. Also found in fetal kidney. According to
CC       PubMed:7607567 it is expressed only in brain tumor glioblastoma
CC       multiforme/astrocytoma and not in other nervous system tumors or normal
CC       fetal or adult tissues.
CC   -!- MISCELLANEOUS: [Isoform 2]: Highly expressed in glioblastomas.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA82731.3; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U16307; AAA82731.3; ALT_FRAME; mRNA.
DR   EMBL; X91911; CAA63005.1; -; mRNA.
DR   EMBL; AF400440; AAK92489.1; -; mRNA.
DR   EMBL; EF667354; ABV21587.1; -; mRNA.
DR   EMBL; BC012510; AAH12510.1; -; mRNA.
DR   CCDS; CCDS9011.1; -. [P48060-1]
DR   PIR; JC4131; JC4131.
DR   PIR; JC5308; JC5308.
DR   RefSeq; NP_006842.2; NM_006851.2. [P48060-1]
DR   PDB; 3Q2R; X-ray; 2.20 A; A=22-220.
DR   PDB; 3Q2U; X-ray; 1.85 A; A=22-220.
DR   PDBsum; 3Q2R; -.
DR   PDBsum; 3Q2U; -.
DR   SMR; P48060; -.
DR   BioGRID; 116200; 9.
DR   IntAct; P48060; 9.
DR   MINT; P48060; -.
DR   STRING; 9606.ENSP00000266659; -.
DR   DrugBank; DB05337; SOT-107.
DR   iPTMnet; P48060; -.
DR   PhosphoSitePlus; P48060; -.
DR   BioMuta; GLIPR1; -.
DR   DMDM; 27735198; -.
DR   EPD; P48060; -.
DR   jPOST; P48060; -.
DR   MassIVE; P48060; -.
DR   MaxQB; P48060; -.
DR   PaxDb; P48060; -.
DR   PeptideAtlas; P48060; -.
DR   PRIDE; P48060; -.
DR   ProteomicsDB; 55851; -. [P48060-1]
DR   ProteomicsDB; 55852; -. [P48060-2]
DR   Antibodypedia; 2474; 150 antibodies.
DR   DNASU; 11010; -.
DR   Ensembl; ENST00000266659; ENSP00000266659; ENSG00000139278. [P48060-1]
DR   GeneID; 11010; -.
DR   KEGG; hsa:11010; -.
DR   UCSC; uc001sxs.4; human. [P48060-1]
DR   CTD; 11010; -.
DR   DisGeNET; 11010; -.
DR   EuPathDB; HostDB:ENSG00000139278.9; -.
DR   GeneCards; GLIPR1; -.
DR   HGNC; HGNC:17001; GLIPR1.
DR   HPA; ENSG00000139278; Tissue enhanced (blood).
DR   MIM; 602692; gene.
DR   neXtProt; NX_P48060; -.
DR   OpenTargets; ENSG00000139278; -.
DR   PharmGKB; PA134988403; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   GeneTree; ENSGT00940000160727; -.
DR   HOGENOM; CLU_035730_2_0_1; -.
DR   InParanoid; P48060; -.
DR   OMA; LWVKHKY; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; P48060; -.
DR   TreeFam; TF316148; -.
DR   PathwayCommons; P48060; -.
DR   Reactome; R-HSA-1989781; PPARA activates gene expression.
DR   Reactome; R-HSA-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 11010; 4 hits in 865 CRISPR screens.
DR   ChiTaRS; GLIPR1; human.
DR   EvolutionaryTrace; P48060; -.
DR   GeneWiki; GLIPR1; -.
DR   GenomeRNAi; 11010; -.
DR   Pharos; P48060; Tbio.
DR   PRO; PR:P48060; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P48060; protein.
DR   Bgee; ENSG00000139278; Expressed in leukocyte and 232 other tissues.
DR   ExpressionAtlas; P48060; baseline and differential.
DR   Genevisible; P48060; HS.
DR   GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
DR   GO; GO:0019216; P:regulation of lipid metabolic process; TAS:Reactome.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Membrane; Polymorphism;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..266
FT                   /note="Glioma pathogenesis-related protein 1"
FT                   /id="PRO_0000006270"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          38..175
FT                   /note="SCP"
FT   VAR_SEQ         142..266
FT                   /note="VWADSYKVGCAVQFCPKVSGFDALSNGAHFICNYGPGGNYPTWPYKRGATCS
FT                   ACPNNDKCLDNLCVNRQRDQVKRYYSVVYPGWPIYPRNRYTSLFLIVNSVILILSVIIT
FT                   ILVQHKYPNLVLLD -> SQERGRDPNPKRGFLNLARENPGLFGQIVTKLAAQFNFALK
FT                   FLALTLFPMEHILYATTDQEGITQLGHIREEPPAVPAPIMTSVWTISVLTDSETK (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17825796"
FT                   /id="VSP_043902"
FT   VARIANT         163
FT                   /note="D -> E (in dbSNP:rs28932170)"
FT                   /id="VAR_061128"
FT   VARIANT         211
FT                   /note="R -> Q (in dbSNP:rs3736392)"
FT                   /id="VAR_048833"
FT   CONFLICT        257
FT                   /note="H -> L (in Ref. 3; CAA63005)"
FT                   /evidence="ECO:0000305"
FT   HELIX           31..46
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          52..54
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   HELIX           62..72
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          76..78
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          97..104
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   TURN            105..107
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   HELIX           110..118
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   HELIX           119..123
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   TURN            126..129
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          130..133
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   HELIX           136..141
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          148..157
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          167..177
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          188..190
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   TURN            191..194
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          200..202
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   STRAND          205..207
FT                   /evidence="ECO:0000244|PDB:3Q2U"
FT   HELIX           209..212
FT                   /evidence="ECO:0000244|PDB:3Q2U"
SQ   SEQUENCE   266 AA;  30366 MW;  C0466C085EFB2B7A CRC64;
     MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW
     DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE
     IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN
     YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV
     NSVILILSVI ITILVQHKYP NLVLLD
//