ID TTP_RAT Reviewed; 320 AA. AC P47973; Q54AH1; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 03-NOV-2009, entry version 67. DE RecName: Full=Tristetraproline; DE Short=TTP; DE AltName: Full=Zinc finger protein 36; DE Short=Zfp-36; DE AltName: Full=Protein TIS11A; DE Short=TIS11; GN Name=Zfp36; Synonyms=Tis11a; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=92380517; PubMed=1511903; DOI=10.1016/0378-1119(92)90202-Z; RA Kaneda N., Oshima M., Chung S.Y., Guroff G.; RT "Sequence of a rat TIS11 cDNA, an immediate early gene induced by RT growth factors and phorbol esters."; RL Gene 118:289-291(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=21012452; PubMed=11129950; DOI=10.1023/A:1007172316657; RA Kaneda N., Murata T., Niimi Y., Minamiyama M.; RT "Cloning and characterization of the rat TIS11 gene."; RL Mol. Cell. Biochem. 213:119-126(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pituitary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Probable regulatory protein with a novel zinc finger CC structure involved in regulating the response to growth factors. CC Has been experimentally shown to be able to bind zinc. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Contains 2 C3H1-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X63369; CAA44970.1; -; mRNA. DR EMBL; AB025017; BAB12432.1; -; Genomic_DNA. DR EMBL; BC060308; AAH60308.1; -; mRNA. DR IPI; IPI00192126; -. DR PIR; JC1255; JC1255. DR RefSeq; NP_579824.2; -. DR UniGene; Rn.82737; -. DR HSSP; P22893; 1M9O. DR SMR; P47973; 94-163. DR STRING; P47973; -. DR PhosphoSite; P47973; -. DR PRIDE; P47973; -. DR Ensembl; ENSRNOT00000026661; ENSRNOP00000026661; ENSRNOG00000019673; Rattus norvegicus. DR GeneID; 79426; -. DR KEGG; rno:79426; -. DR UCSC; NM_133290; rat. DR CTD; 79426; -. DR RGD; 620722; Zfp36. DR HOVERGEN; P47973; -. DR OMA; NRISVSE; -. DR NextBio; 614778; -. DR ArrayExpress; P47973; -. DR Genevestigator; P47973; -. DR GermOnline; ENSRNOG00000019673; Rattus norvegicus. DR GO; GO:0005634; C:nucleus; IDA:RGD. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0016563; F:transcription activator activity; TAS:RGD. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW. DR GO; GO:0045893; P:positive regulation of transcription, DNA-d...; TAS:RGD. DR InterPro; IPR000571; Znf_CCCH. DR Pfam; PF00642; zf-CCCH; 2. DR SMART; SM00356; ZnF_C3H1; 2. DR PROSITE; PS50103; ZF_C3H1; 2. PE 2: Evidence at transcript level; KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Repeat; Zinc; KW Zinc-finger. FT CHAIN 1 320 Tristetraproline. FT /FTId=PRO_0000089165. FT REPEAT 64 68 P-P-P-P-G. FT REPEAT 191 195 P-P-P-P-G. FT REPEAT 212 216 P-P-P-P-G. FT ZN_FING 96 124 C3H1-type 1. FT ZN_FING 134 162 C3H1-type 2. FT MOD_RES 53 53 Phosphoserine (By similarity). FT MOD_RES 81 81 Phosphoserine (By similarity). FT MOD_RES 83 83 Phosphoserine (By similarity). FT MOD_RES 86 86 Phosphoserine (By similarity). FT MOD_RES 179 179 Phosphoserine (By similarity). FT MOD_RES 251 251 Phosphothreonine (By similarity). FT MOD_RES 317 317 Phosphoserine (By similarity). SQ SEQUENCE 320 AA; 33654 MW; CFC597F3C7E5CA76 CRC64; MDLSAIYESL MSMSHDLSPD HGGTESSGGL WNINSSDSIP SGVTSRLTGR STSLVEGRSC SWVPPPPGFA PLAPRPGPEL SPSPTSPTAT PTTSSRYKTE LCRTYSESGR CRYGAKCQFA HGPGELRQAN RHPKYKTELC HKFYLQGRCP YGSRCHFIHN PTEDLALPGQ PHVLRQSISF SGLPSGRRTS PPPPGFSGPS LSSCSFSPSS SPPPPGDLPL SPSAFSAAPG TPVSRRDPTP ACCPSCRRST TPSTIWGPLG GLARSPSAHS LGSDPDDYAS SGSSLGGSDS PVFEAGVFGP PQPPAPPRRL PIFNRISVSE //