ID TTP_RAT STANDARD; PRT; 320 AA. AC P47973; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE TRISTETRAPROLINE (TTP) (TIS11A) (TIS11) (ZFP-36). GN ZFP36 OR TIS11A. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 92380517. RA Kaneda N., Oshima M., Chung S.Y., Guroff G.; RT "Sequence of a rat TIS11 cDNA, an immediate early gene induced by RT growth factors and phorbol esters."; RL Gene 118:289-291(1992). CC -!- FUNCTION: PROBABLE REGULATORY PROTEIN WITH A NOVEL ZINC FINGER CC STRUCTURE INVOLVED IN REGULATING THE RESPONSE TO GROWTH FACTORS. CC HAS BEEN EXPERIMENTALY SHOWN TO BE ABLE TO BIND ZINC. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: CONTAINS 2 CX(8)CX(5)CX(3)H-TYPE ZINC FINGERS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X63369; CAA44970.1; -. DR INTERPRO; IPR000571; -. DR PFAM; PF00642; zf-CCCH; 2. KW Nuclear protein; Repeat; Metal-binding; Zinc-finger; DNA-binding; KW Phosphorylation. FT REPEAT 64 68 P-P-P-P-G. FT REPEAT 191 195 P-P-P-P-G. FT REPEAT 212 216 P-P-P-P-G. FT ZN_FING 102 121 CX(8)CX(5)CX(3)H-TYPE. FT ZN_FING 140 159 CX(8)CX(5)CX(3)H-TYPE. FT MOD_RES 221 221 PHOSPHORYLATION (BY MAPK) (BY FT SIMILARITY). SQ SEQUENCE 320 AA; 33653 MW; CFC597F3C7E5CA76 CRC64; MDLSAIYESL MSMSHDLSPD HGGTESSGGL WNINSSDSIP SGVTSRLTGR STSLVEGRSC SWVPPPPGFA PLAPRPGPEL SPSPTSPTAT PTTSSRYKTE LCRTYSESGR CRYGAKCQFA HGPGELRQAN RHPKYKTELC HKFYLQGRCP YGSRCHFIHN PTEDLALPGQ PHVLRQSISF SGLPSGRRTS PPPPGFSGPS LSSCSFSPSS SPPPPGDLPL SPSAFSAAPG TPVSRRDPTP ACCPSCRRST TPSTIWGPLG GLARSPSAHS LGSDPDDYAS SGSSLGGSDS PVFEAGVFGP PQPPAPPRRL PIFNRISVSE //