ID TTP_RAT STANDARD; PRT; 320 AA. AC P47973; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Tristetraproline (TTP) (Zinc finger protein 36) (Zfp-36) (TIS11A DE protein) (TIS11). GN Name=Zfp36; Synonyms=Tis11a; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=92380517; PubMed=1511903; DOI=10.1016/0378-1119(92)90202-Z; RA Kaneda N., Oshima M., Chung S.Y., Guroff G.; RT "Sequence of a rat TIS11 cDNA, an immediate early gene induced by RT growth factors and phorbol esters."; RL Gene 118:289-291(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pituitary; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable regulatory protein with a novel zinc finger CC structure involved in regulating the response to growth factors. CC Has been experimentaly shown to be able to bind zinc. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Contains 2 C3H1-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X63369; CAA44970.1; -; mRNA. DR EMBL; BC060308; AAH60308.1; -; mRNA. DR PIR; JC1255; JC1255. DR HSSP; P22893; 1M9O. DR SMR; P47973; 94-163. DR Ensembl; ENSRNOG00000019673; Rattus norvegicus. DR RGD; 620722; Zfp36. DR GO; GO:0005737; C:cytoplasm; IDA. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0016563; F:transcriptional activator activity; TAS. DR GO; GO:0045893; P:positive regulation of transcription, DNA-d...; TAS. DR InterPro; IPR000571; Znf_CCCH. DR Pfam; PF00642; zf-CCCH; 2. DR SMART; SM00356; ZnF_C3H1; 2. KW DNA-binding; Metal-binding; Nuclear protein; Phosphorylation; Repeat; KW Zinc; Zinc-finger. FT REPEAT 64 68 P-P-P-P-G. FT REPEAT 191 195 P-P-P-P-G. FT REPEAT 212 216 P-P-P-P-G. FT ZN_FING 102 121 C3H1-type 1. FT ZN_FING 140 159 C3H1-type 2. FT MOD_RES 221 221 Phosphoserine (by MAPK) (By similarity). SQ SEQUENCE 320 AA; 33654 MW; CFC597F3C7E5CA76 CRC64; MDLSAIYESL MSMSHDLSPD HGGTESSGGL WNINSSDSIP SGVTSRLTGR STSLVEGRSC SWVPPPPGFA PLAPRPGPEL SPSPTSPTAT PTTSSRYKTE LCRTYSESGR CRYGAKCQFA HGPGELRQAN RHPKYKTELC HKFYLQGRCP YGSRCHFIHN PTEDLALPGQ PHVLRQSISF SGLPSGRRTS PPPPGFSGPS LSSCSFSPSS SPPPPGDLPL SPSAFSAAPG TPVSRRDPTP ACCPSCRRST TPSTIWGPLG GLARSPSAHS LGSDPDDYAS SGSSLGGSDS PVFEAGVFGP PQPPAPPRRL PIFNRISVSE //