ID TTP_RAT STANDARD; PRT; 320 AA. AC P47973; DT 01-OCT-1996 (Rel. 34, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Tristetraproline (TTP) (TIS11A protein) (TIS11) (Zinc finger protein DE 36) (Zfp-36). GN ZFP36 OR TIS11A. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=92380517; PubMed=1511903; RA Kaneda N., Oshima M., Chung S.Y., Guroff G.; RT "Sequence of a rat TIS11 cDNA, an immediate early gene induced by RT growth factors and phorbol esters."; RL Gene 118:289-291(1992). CC -!- FUNCTION: Probable regulatory protein with a novel zinc finger CC structure involved in regulating the response to growth factors. CC Has been experimentaly shown to be able to bind zinc. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Contains 2 C3H1-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X63369; CAA44970.1; -. DR PIR; JC1255; JC1255. DR HSSP; P22893; 1M9O. DR RGD; 620722; Zfp36. DR InterPro; IPR000571; Znf_CCCH. DR Pfam; PF00642; zf-CCCH; 2. DR SMART; SM00356; ZnF_C3H1; 2. KW Nuclear protein; Repeat; Metal-binding; Zinc-finger; DNA-binding; KW Phosphorylation. FT REPEAT 64 68 P-P-P-P-G. FT REPEAT 191 195 P-P-P-P-G. FT REPEAT 212 216 P-P-P-P-G. FT ZN_FING 102 121 C3H1-type 1. FT ZN_FING 140 159 C3H1-type 2. FT MOD_RES 221 221 Phosphoserine (by MAPK) (By similarity). SQ SEQUENCE 320 AA; 33653 MW; CFC597F3C7E5CA76 CRC64; MDLSAIYESL MSMSHDLSPD HGGTESSGGL WNINSSDSIP SGVTSRLTGR STSLVEGRSC SWVPPPPGFA PLAPRPGPEL SPSPTSPTAT PTTSSRYKTE LCRTYSESGR CRYGAKCQFA HGPGELRQAN RHPKYKTELC HKFYLQGRCP YGSRCHFIHN PTEDLALPGQ PHVLRQSISF SGLPSGRRTS PPPPGFSGPS LSSCSFSPSS SPPPPGDLPL SPSAFSAAPG TPVSRRDPTP ACCPSCRRST TPSTIWGPLG GLARSPSAHS LGSDPDDYAS SGSSLGGSDS PVFEAGVFGP PQPPAPPRRL PIFNRISVSE //