ID   V1BR_HUMAN              Reviewed;         424 AA.
AC   P47901; B0M0J6; Q5TZ00;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   22-FEB-2012, entry version 100.
DE   RecName: Full=Vasopressin V1b receptor;
DE            Short=V1bR;
DE   AltName: Full=AVPR V1b;
DE   AltName: Full=AVPR V3;
DE   AltName: Full=Antidiuretic hormone receptor 1b;
DE   AltName: Full=Vasopressin V3 receptor;
GN   Name=AVPR1B; Synonyms=AVPR3, VPR3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   MEDLINE=95014580; PubMed=7929452;
RA   Sugimoto T., Saito M., Mochizuki S., Watanabe Y., Hashimoto S.,
RA   Kawashima H.;
RT   "Molecular cloning and functional expression of a cDNA encoding the
RT   human V1b vasopressin receptor.";
RL   J. Biol. Chem. 269:27088-27092(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   MEDLINE=95104418; PubMed=7805841; DOI=10.1016/0014-5793(94)01268-7;
RA   de Keyzer Y., Auzan C., Lenne F., Beldjord C., Thibonnier M.,
RA   Bertagna X., Clauser E.;
RT   "Cloning and characterization of the human V3 pituitary vasopressin
RT   receptor.";
RL   FEBS Lett. 356:215-220(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung carcinoma;
RX   MEDLINE=98019904; PubMed=9357056; DOI=10.1016/S0196-9781(97)00072-7;
RA   North W.G., Fay M.J., Longo K.A., Du J.;
RT   "Functional vasopressin V1 type receptors are present in variant as
RT   well as classical forms of small-cell carcinoma.";
RL   Peptides 18:985-993(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=98240982; PubMed=9581826;
RA   North W.G., Fay M.J., Longo K.A., Du J.;
RT   "Expression of all known vasopressin receptor subtypes by small cell
RT   tumors implies a multifaceted role for this neuropeptide.";
RL   Cancer Res. 58:1866-1871(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20076392; PubMed=10607899; DOI=10.1016/S0378-1119(99)00468-0;
RA   Rene P., Lenne F., Ventura M.A., Bertagna X., de Keyzer Y.;
RT   "Nucleotide sequence and structural organization of the human
RT   vasopressin pituitary receptor (V3) gene.";
RL   Gene 241:57-64(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Kaighin V.A., Martin A.L., Aronstam R.S.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASN-65; ARG-191;
RP   GLY-267 AND HIS-364.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [9]
RP   VARIANTS ASN-65 AND HIS-364.
RX   PubMed=17909131; DOI=10.1001/archpsyc.64.10.1189;
RA   Dempster E.L., Burcescu I., Wigg K., Kiss E., Baji I., Gadoros J.,
RA   Tamas Z., Kennedy J.L., Vetro A., Kovacs M., Barr C.L.;
RT   "Evidence of an association between the vasopressin V1b receptor gene
RT   (AVPR1B) and childhood-onset mood disorders.";
RL   Arch. Gen. Psychiatry 64:1189-1195(2007).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily.
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/avpr1b/";
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DR   EMBL; D31833; BAA06621.1; -; mRNA.
DR   EMBL; L37112; AAA65687.1; -; mRNA.
DR   EMBL; AF030512; AAB84293.1; -; mRNA.
DR   EMBL; AF101726; AAD17892.1; -; mRNA.
DR   EMBL; AF152238; AAF33681.1; -; Genomic_DNA.
DR   EMBL; EU432111; ABY87910.1; -; mRNA.
DR   EMBL; DQ194816; ABA03171.1; -; Genomic_DNA.
DR   EMBL; BX571818; CAH73262.1; -; Genomic_DNA.
DR   IPI; IPI00026826; -.
DR   PIR; A55089; A55089.
DR   RefSeq; NP_000698.1; NM_000707.3.
DR   UniGene; Hs.1372; -.
DR   ProteinModelPortal; P47901; -.
DR   SMR; P47901; 38-356.
DR   STRING; P47901; -.
DR   DMDM; 1351392; -.
DR   PRIDE; P47901; -.
DR   Ensembl; ENST00000367126; ENSP00000356094; ENSG00000198049.
DR   GeneID; 553; -.
DR   KEGG; hsa:553; -.
DR   UCSC; uc001hds.2; human.
DR   CTD; 553; -.
DR   GeneCards; GC01P206223; -.
DR   H-InvDB; HIX0028519; -.
DR   HGNC; HGNC:896; AVPR1B.
DR   MIM; 600264; gene.
DR   neXtProt; NX_P47901; -.
DR   PharmGKB; PA25188; -.
DR   eggNOG; NOG299951; -.
DR   GeneTree; ENSGT00650000092859; -.
DR   HOGENOM; HBG402956; -.
DR   HOVERGEN; HBG105710; -.
DR   InParanoid; P47901; -.
DR   KO; K04227; -.
DR   OMA; DSTNVAF; -.
DR   OrthoDB; EOG4640C2; -.
DR   PhylomeDB; P47901; -.
DR   Reactome; REACT_111102; Signal Transduction.
DR   DrugBank; DB00035; Desmopressin.
DR   DrugBank; DB02638; Terlipressin.
DR   DrugBank; DB00067; Vasopressin.
DR   NextBio; 2285; -.
DR   ArrayExpress; P47901; -.
DR   Bgee; P47901; -.
DR   CleanEx; HS_AVPR1B; -.
DR   Genevestigator; P47901; -.
DR   GermOnline; ENSG00000198049; Homo sapiens.
DR   GO; GO:0005768; C:endosome; TAS:ProtInc.
DR   GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR   GO; GO:0005080; F:protein kinase C binding; TAS:ProtInc.
DR   GO; GO:0005000; F:vasopressin receptor activity; TAS:ProtInc.
DR   GO; GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
DR   GO; GO:0007204; P:elevation of cytosolic calcium ion concentration; TAS:ProtInc.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR000628; Vprs_rcpt_V1B.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00897; VASOPRSNV1BR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    424       Vasopressin V1b receptor.
FT                                /FTId=PRO_0000070203.
FT   TOPO_DOM      1     35       Extracellular (Potential).
FT   TRANSMEM     36     59       Helical; Name=1; (Potential).
FT   TOPO_DOM     60     71       Cytoplasmic (Potential).
FT   TRANSMEM     72     93       Helical; Name=2; (Potential).
FT   TOPO_DOM     94    108       Extracellular (Potential).
FT   TRANSMEM    109    130       Helical; Name=3; (Potential).
FT   TOPO_DOM    131    151       Cytoplasmic (Potential).
FT   TRANSMEM    152    173       Helical; Name=4; (Potential).
FT   TOPO_DOM    174    201       Extracellular (Potential).
FT   TRANSMEM    202    222       Helical; Name=5; (Potential).
FT   TOPO_DOM    223    283       Cytoplasmic (Potential).
FT   TRANSMEM    284    303       Helical; Name=6; (Potential).
FT   TOPO_DOM    304    321       Extracellular (Potential).
FT   TRANSMEM    322    341       Helical; Name=7; (Potential).
FT   TOPO_DOM    342    424       Cytoplasmic (Potential).
FT   CARBOHYD     21     21       N-linked (GlcNAc...) (Potential).
FT   DISULFID    107    186       By similarity.
FT   VARIANT      65     65       K -> N (in dbSNP:rs35369693).
FT                                /FTId=VAR_025159.
FT   VARIANT     191    191       G -> R (in dbSNP:rs33990840).
FT                                /FTId=VAR_025160.
FT   VARIANT     224    224       H -> Q (in dbSNP:rs3891058).
FT                                /FTId=VAR_061228.
FT   VARIANT     267    267       S -> G.
FT                                /FTId=VAR_025161.
FT   VARIANT     364    364       R -> H (in dbSNP:rs28632197).
FT                                /FTId=VAR_025162.
SQ   SEQUENCE   424 AA;  46971 MW;  35190281D3EDB6A7 CRC64;
     MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG
     QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA
     STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG
     SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG
     GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV
     QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ
     PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE
     TIIF
//