ID AL3A2_MOUSE Reviewed; 484 AA. AC P47740; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 09-FEB-2010, entry version 78. DE RecName: Full=Fatty aldehyde dehydrogenase; DE EC=1.2.1.3; DE AltName: Full=Aldehyde dehydrogenase family 3 member A2; DE AltName: Full=Aldehyde dehydrogenase 3; GN Name=Aldh3a2; Synonyms=Ahd-3, Ahd3, Aldh3, Aldh4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6 X CBA; TISSUE=Liver; RX MEDLINE=96226402; PubMed=8634152; DOI=10.1089/dna.1996.15.235; RA Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.; RT "Mouse microsomal class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, RT inducibility by dioxin and clofibrate, and genetic mapping."; RL DNA Cell Biol. 15:235-245(1996). CC -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass CC membrane protein; Cytoplasmic side. CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U14390; AAB06232.1; -; mRNA. DR IPI; IPI00761984; -. DR UniGene; Mm.398221; -. DR SMR; P47740; 5-443. DR STRING; P47740; -. DR PRIDE; P47740; -. DR Ensembl; ENSMUST00000074127; ENSMUSP00000073764; ENSMUSG00000010025; Mus musculus. DR MGI; MGI:1353452; Aldh3a2. DR eggNOG; roNOG08034; -. DR HOVERGEN; P47740; -. DR BRENDA; 1.2.1.3; 244. DR ArrayExpress; P47740; -. DR Bgee; P47740; -. DR CleanEx; MM_ALDH3A2; -. DR Genevestigator; P47740; -. DR GermOnline; ENSMUSG00000010025; Mus musculus. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:MGI. DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC. DR GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro. DR GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR016161; Ald_DH/histidinol_DH. DR InterPro; IPR016160; Ald_DH_CS. DR InterPro; IPR016162; Ald_DH_N. DR InterPro; IPR015590; Aldehyde_DH. DR InterPro; IPR012394; Aldehyde_DH_NAD(P). DR Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1. DR PANTHER; PTHR11699; Aldehyde_dehyd; 1. DR PANTHER; PTHR11699:SF15; ALDH; 1. DR Pfam; PF00171; Aldedh; 1. DR PIRSF; PIRSF036492; ALDH; 1. DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. PE 2: Evidence at transcript level; KW Endoplasmic reticulum; Membrane; NAD; Oxidoreductase; Transmembrane. FT CHAIN 1 484 Fatty aldehyde dehydrogenase. FT /FTId=PRO_0000056475. FT TOPO_DOM 1 463 Cytoplasmic. FT TRANSMEM 464 480 Potential. FT NP_BIND 185 190 NAD (Potential). FT MOTIF 481 484 Prevents secretion from ER (By FT similarity). FT ACT_SITE 207 207 By similarity. FT ACT_SITE 241 241 By similarity. SQ SEQUENCE 484 AA; 53943 MW; 098A49260D376C81 CRC64; MERQVLRLRQ AFRSGRSRLL RFRLQQLEAL RRMVQEREKE ILAAIAADLS KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTMQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY AIVNGGIPET TELLKQRFDH ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRVA WGKYMNCGQT CIAPDYILCE ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN FINDREKPLA LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDAFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV KDQL //