ID DHA4_MOUSE STANDARD; PRT; 484 AA. AC P47740; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 15-JUN-2002 (Rel. 41, Last annotation update) DE Fatty aldehyde dehydrogenase (EC 1.2.1.3) (Aldehyde dehydrogenase, DE microsomal) (ALDH class 3). GN ALDH3A2 OR ALDH4 OR ALDH3 OR AHD3 OR AHD-3. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6 X CBA; TISSUE=Liver; RX MEDLINE=96226402; PubMed=8634152; RA Vasiliou V., Kozak C.A., Lindahl R., Nebert D.W.; RT "Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, RT inducibility by dioxin and clofibrate, and genetic mapping."; RL DNA Cell Biol. 15:235-245(1996). CC -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = an acid + NADH. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC SURFACE OF THE ENDOPLASMIC CC RETICULUM MEMBRANE. CC -!- SIMILARITY: BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U14390; AAB06232.1; -. DR HSSP; P11883; 1AD3. DR MGD; MGI:1353452; Aldh3a2. DR InterPro; IPR002086; Aldehyde_dehydr. DR Pfam; PF00171; aldedh; 1. DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. KW Oxidoreductase; NAD; Endoplasmic reticulum; Microsome; Transmembrane. FT DOMAIN 1 463 CYTOPLASMIC. FT TRANSMEM 464 480 POTENTIAL. FT NP_BIND 185 190 NAD (ADP PART) (POTENTIAL). FT ACT_SITE 207 207 BY SIMILARITY. FT ACT_SITE 241 241 BY SIMILARITY. FT SITE 481 484 PREVENT SECRETION FROM ER FT (BY SIMILARITY). SQ SEQUENCE 484 AA; 53942 MW; 098A49260D376C81 CRC64; MERQVLRLRQ AFRSGRSRLL RFRLQQLEAL RRMVQEREKE ILAAIAADLS KSELNAYSHE VITILGEIDF MLGNLPELAS ARPAKKNLLT MMDEAYVQPE PLGVVLIIGA WNYPFVLTMQ PLVGAIAAGN AAIVKPSELS ENTAKILAEL LPQYLDQDLY AIVNGGIPET TELLKQRFDH ILYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDRDC DLDVACRRVA WGKYMNCGQT CIAPDYILCE ASLQNQIVQK IKETVKDFYG ENIKASPDYE RIINLRHFKR LQSLLKGQKI AFGGEMDEAT RYLAPTILTD VDPNSKVMQE EIFGPILPIV SVKNVDEAIN FINDREKPLA LYVFSRNNKL IKRVIDETSS GGVTGNDVIM HFTVNSLPFG GVGASGMGAY HGKYSFDAFS HQRPCLLKGL KGESVNKLRY PPNSESKVSW AKFFLLKQFN KGRLGMLLFV CLVAVAAVIV KDQL //