ID CDD_MYCGE Reviewed; 130 AA. AC P47298; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 24-JUN-2015, entry version 96. DE RecName: Full=Cytidine deaminase; DE Short=CDA; DE EC=3.5.4.5; DE AltName: Full=Cytidine aminohydrolase; GN Name=cdd; OrderedLocusNames=MG052; OS Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195). OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma. OX NCBI_TaxID=243273; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33530 / G-37 / NCTC 10195; RX PubMed=7569993; DOI=10.1126/science.270.5235.397; RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M., RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.; RT "The minimal gene complement of Mycoplasma genitalium."; RL Science 270:397-403(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 108-130. RC STRAIN=ATCC 33530 / G-37 / NCTC 10195; RX PubMed=8253680; RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III; RT "A survey of the Mycoplasma genitalium genome by using random RT sequencing."; RL J. Bacteriol. 175:7918-7930(1993). CC -!- FUNCTION: This enzyme scavenges exogenous and endogenous cytidine CC and 2'-deoxycytidine for UMP synthesis. {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3). CC -!- CATALYTIC ACTIVITY: 2'deoxycytidine + H(2)O = 2'-deoxyuridine + CC NH(3). CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; CC Note=Binds 1 zinc ion. {ECO:0000250}; CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase CC family. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 CMP/dCMP-type deaminase domain. CC {ECO:0000255|PROSITE-ProRule:PRU01083}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L43967; AAC71268.1; -; Genomic_DNA. DR EMBL; U02108; AAD12378.1; -; Genomic_DNA. DR PIR; G64205; G64205. DR RefSeq; NP_072712.1; NC_000908.2. DR RefSeq; WP_010869308.1; NZ_AAGX01000003.1. DR ProteinModelPortal; P47298; -. DR STRING; 243273.MgenG_010200001135; -. DR EnsemblBacteria; AAC71268; AAC71268; MG_052. DR KEGG; mge:MG_052; -. DR PATRIC; 20009484; VBIMycGen98045_0052. DR eggNOG; COG0295; -. DR KO; K01489; -. DR OMA; ISPCAGC; -. DR OrthoDB; EOG6XDH25; -. DR BioCyc; MGEN243273:GH2R-52-MONOMER; -. DR Proteomes; UP000000807; Chromosome. DR GO; GO:0004126; F:cytidine deaminase activity; IEA:UniProtKB-EC. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd. DR InterPro; IPR002125; CMP_dCMP_Zn-bd. DR InterPro; IPR006262; Cyt_deam_tetra. DR InterPro; IPR016193; Cytidine_deaminase-like. DR Pfam; PF00383; dCMP_cyt_deam_1; 1. DR SUPFAM; SSF53927; SSF53927; 1. DR TIGRFAMs; TIGR01354; cyt_deam_tetra; 1. DR PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1. DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1. PE 3: Inferred from homology; KW Complete proteome; Hydrolase; Metal-binding; Zinc. FT CHAIN 1 130 Cytidine deaminase. FT /FTId=PRO_0000171679. FT DOMAIN 3 130 CMP/dCMP-type deaminase. FT {ECO:0000255|PROSITE-ProRule:PRU01083}. FT REGION 43 45 Substrate binding. {ECO:0000250}. FT ACT_SITE 56 56 Proton donor. {ECO:0000250}. FT METAL 54 54 Zinc; catalytic. {ECO:0000250}. FT METAL 88 88 Zinc; catalytic. {ECO:0000250}. FT METAL 91 91 Zinc; catalytic. {ECO:0000250}. SQ SEQUENCE 130 AA; 14974 MW; 1DF02B1718F9495F CRC64; MKVNLEWIIK QLQMIVKRAY TPFSNFKVAC MIIANNQTFF GVNIENSSFP VTLCAERSAI ASMVTSGHRK IDYVFVYFNT KNKSNSPCGM CRQNLLEFSH QKTKLFCIDN DSSYKQFSID ELLMNGFKKS //