ID CDD_MYCGE STANDARD; PRT; 130 AA. AC P47298; DT 01-FEB-1996 (Rel. 33, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA). GN Name=cdd; OrderedLocusNames=MG052; OS Mycoplasma genitalium. OC Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma. OX NCBI_TaxID=2097; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33530 / G-37; RX MEDLINE=96026346; PubMed=7569993; RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M., RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.; RT "The minimal gene complement of Mycoplasma genitalium."; RL Science 270:397-403(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 108-130. RC STRAIN=ATCC 33530 / G-37; RX MEDLINE=94075230; PubMed=8253680; RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III; RT "A survey of the Mycoplasma genitalium genome by using random RT sequencing."; RL J. Bacteriol. 175:7918-7930(1993). CC -!- FUNCTION: This enzyme scavenge exogenous and endogenous cytidine CC and 2'-deoxycytidine for UMP synthesis (By similarity). CC -!- CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3). CC -!- COFACTOR: Binds 1 zinc ion (By similarity). CC -!- SUBUNIT: Homodimer (By similarity). CC -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U39684; AAC71268.1; -; Genomic_DNA. DR EMBL; U02108; AAD12378.1; -; Genomic_DNA. DR PIR; G64205; G64205. DR HSSP; P13652; 1CTT. DR TIGR; MG052; -. DR InterPro; IPR002125; CMP_dCMP_Zn_bd. DR InterPro; IPR006262; Cyt_deam_tetra. DR Pfam; PF00383; dCMP_cyt_deam; 1. DR PIRSF; PIRSF001250; Cyd_deaminase; 1. DR TIGRFAMs; TIGR01354; cyt_deam_tetra; 1. DR PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1. KW Complete proteome; Hydrolase; Metal-binding; Zinc. FT REGION 43 45 Substrate binding (By similarity). FT ACT_SITE 56 56 Proton donor (By similarity). FT METAL 54 54 Zinc (catalytic) (By similarity). FT METAL 88 88 Zinc (catalytic) (By similarity). FT METAL 91 91 Zinc (catalytic) (By similarity). SQ SEQUENCE 130 AA; 14974 MW; 1DF02B1718F9495F CRC64; MKVNLEWIIK QLQMIVKRAY TPFSNFKVAC MIIANNQTFF GVNIENSSFP VTLCAERSAI ASMVTSGHRK IDYVFVYFNT KNKSNSPCGM CRQNLLEFSH QKTKLFCIDN DSSYKQFSID ELLMNGFKKS //