ID SNG1_YEAST Reviewed; 547 AA. AC P46950; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 1. DT 23-JAN-2007, entry version 42. DE Nitrosoguanidine resistance protein SNG1. GN Name=SNG1; OrderedLocusNames=YGR197C; ORFNames=G7591; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=95272615; PubMed=7753113; DOI=10.1016/0165-7992(95)90037-3; RA Grey M., Pich C.T., Haase E., Brendel M.; RT "SNG1 -- a new gene involved in nitrosoguanidine resistance in RT Saccharomyces cerevisiae."; RL Mutat. Res. 346:207-214(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX MEDLINE=96076633; PubMed=7502584; RA Guerreiro P., Maia e Silva A., Barreiros T., Arroyo J., RA Garcia-Gonzalez M., Garcia-Saez M.I., Rodrigues-Pousada C., RA Nombela C.; RT "The complete sequence of a 9000 bp fragment of the right arm of RT Saccharomyces cerevisiae chromosome VII contains four previously RT unknown open reading frames."; RL Yeast 11:1087-1091(1995). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX MEDLINE=97313265; PubMed=9169869; RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., RA Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., RA Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., RA Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E., RA Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., RA Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., RA Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., RA Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., RA Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., RA Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., RA Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., RA Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., RA Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., RA Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., RA Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., RA Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., RA Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., RA Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., RA Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., RA van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., RA Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., RA Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., RA Zollner A., Kleine K.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."; RL Nature 387:81-84(1997). RN [4] RP INDUCTION. RX PubMed=12529331; DOI=10.1074/jbc.M208549200; RA Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.; RT "A general strategy to uncover transcription factor properties RT identifies a new regulator of drug resistance in yeast."; RL J. Biol. Chem. 278:11427-11432(2003). CC -!- FUNCTION: May function as a N-methyl-N'nitro-N-nitrosoguanidine CC (MNNG) export permease. CC -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein CC (Potential). CC -!- INDUCTION: Transcriptionally regulated by PDR8. CC -!- SIMILARITY: To yeast YJR015W. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X74920; CAA52881.1; -; Genomic_DNA. DR EMBL; X82775; CAA58016.1; -; Genomic_DNA. DR EMBL; Z72982; CAA97224.1; -; Genomic_DNA. DR PIR; S53920; S53920. DR DIP; DIP:8148N; -. DR Ensembl; YGR197C; Saccharomyces cerevisiae. DR GenomeReviews; Y13135_GR; YGR197C. DR KEGG; sce:YGR197C; -. DR SGD; S000003429; SNG1. DR BioCyc; SCER-S28-01:SCER-S28-01-002473-MONOMER; -. DR LinkHub; P46950; -. DR GermOnline; YGR197C; Saccharomyces cerevisiae. DR GO; GO:0042493; P:response to drug; IMP:SGD. KW Complete proteome; Membrane; Transmembrane. FT CHAIN 1 547 Nitrosoguanidine resistance protein SNG1. FT /FTId=PRO_0000072007. FT TRANSMEM 109 129 Potential. FT TRANSMEM 159 179 Potential. FT TRANSMEM 318 338 Potential. FT TRANSMEM 363 383 Potential. FT TRANSMEM 394 414 Potential. FT TRANSMEM 418 438 Potential. FT TRANSMEM 457 477 Potential. FT TRANSMEM 488 508 Potential. FT CONFLICT 117 117 A -> V (in Ref. 1). SQ SEQUENCE 547 AA; 61293 MW; D4421BA2DED55420 CRC64; MTKSVGDEES QYIEDPSFAA AAAFTGGRDG VSYSNQRFAE GSGHSSDLAK SLEDYRPPDE KPSSLSSVGE GGANEEEKGG NDGGPLARIQ TGLFSPRLRN HRKKILSKFV LNNFFIACVC VSLISIYWGA CYGTDRYFFK VKNIVVLQDA PSNTSVQSIS AIIPSLLASV PGTWHIYNAT SFHRKFGTTN STEIDRKIVD LIYDERYWLA LNVKPNATDT LYNSLISQDA NSEFNSSIFF ESVFESGRDP SSVKSTILPL MQQLEVRLQK YYVKEYLPSL MSNITSNDRD LNINMENWAI AGQLLFTYND YRPFADRILM APLQVGLIYC ILLTVLQLSL YGKLHGEMAR VLKPKHILIY RLLISWATYF LLSIGFCTVS AIFRIDFTPA FGRGGFVVYW MSTWLVMMAV GGANENVLSL VIAYCPPYLS IWLMTWIILN ISASFYPMVL NNEFYRYGYI MPIHNAVDIY KVIFLNLTKR KMGRNYGILV AWVALNTSLM PFCMKFAGKK MQKNAMQAAE AAVAAATQRA SRPAEANTDK NNNPPGN //