ID PURK_MYCLE STANDARD; PRT; 439 AA. AC P46701; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT (EC 4.1.1.21) DE (AIR CARBOXYLASE) (AIRC). GN PURK OR B1308_F1_32. OS Mycobacterium leprae. OC Bacteria; Firmicutes; Actinobacteria; Actinobacteridae; OC Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium. OX NCBI_TaxID=1769; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=96084954; PubMed=7489918; RA Doukhan L., Predich M., Nair G., Dussurget O., Mandic-Mulec I., RA Cole S.T., Smith D.R., Smith I.; RT "Genomic organization of the mycobacterial sigma gene cluster."; RL Gene 165:67-70(1995). CC -!- FUNCTION: POSSESSES AN ATPASE ACTIVITY THAT IS DEPENDENT ON THE CC PRESENCE OF AIR (AMINOIMIDAZOLE RIBONUCLEOTIDE). THE ASSOCIATION CC OF PURK AND PURE PRODUCES AN ENZYME COMPLEX CAPABLE OF CONVERTING CC AIR TO CAIR EFFICIENTLY UNDER PHYSIOLOGICAL CONDITION CC (BY SIMILARITY). CC -!- CATALYTIC ACTIVITY: 1-(5-PHOSPHORIBOSYL)-5-AMINO-4-IMIDAZOLE- CC CARBOXYLATE = 1-(5-PHOSPHORIBOSYL)-5-AMINOIMIDAZOLE + CO(2). CC -!- PATHWAY: SIXTH STEP IN DE NOVO PURINE BIOSYNTHESIS. CC -!- SUBUNIT: HOMODIMER (BY SIMILARITY). CC -!- SIMILARITY: BELONGS TO THE PURK / PURT FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U00012; AAA85935.1; -. KW Purine biosynthesis; Lyase; Decarboxylase. SQ SEQUENCE 439 AA; 47306 MW; 288C5DD5EE7508EE CRC64; MMAVPSRCSL GVAPLVAMVG GGQLARMTHQ AAIALGQTLR VLATAADEPA AQVTPDVVIG SHTDLEDLRR VALGADALTF DHEHVPTELL DKLVAEGINV APSPQALVHA QDKLVMRRRL AALGAAMPRF MALDSVDDLA EIDAFAQRLT GSKDAPMVVK AVRGGYDGRG VQMVRDSAHA REVASGYLVD GMPVLVEERV ELRRELSALV ARSPFGQGAA WPVVETVQRD GICVLVVAPA LALADDLASA AQQLALRLAA ELGVVGVFAV ELFETADGAL LVNELAMRPH NSGHWTMDGA RTSQFEQHLR AVLDYPLGET DAVAPVTVMV NVLGAPQPPT LSVVTMDERL HHLFARMPDA RVHLYDKVER PGRKVGHINF RGTDKDRKNP TKLRERAELA AHWLSHGQWT DGWDPHRAGD DVVEISLACG GRNDAQRQR //