ID ADF1_CANAL Reviewed; 612 AA. AC P46589; A0A1D8PKL9; Q5A2X5; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 10-FEB-2021, entry version 82. DE RecName: Full=Adherence factor; DE AltName: Full=Adhesion and aggregation mediating surface antigen; GN Name=ADF1; Synonyms=AAF1; OrderedLocusNames=CAALFM_C306470WA; GN ORFNames=CaO19.7436; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Jiang W., Finkler A., Koltin Y.; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [3] RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-612. RC STRAIN=ATCC 36082; RA Edwards J.E.; RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Surface antigen mediating adhesion and aggregation in CC S.cerevisiae. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U44747; AAA86758.1; -; Genomic_DNA. DR EMBL; CP017625; AOW28653.1; -; Genomic_DNA. DR EMBL; U18983; AAA62506.1; -; Genomic_DNA. DR RefSeq; XP_716097.1; XM_711004.1. DR SMR; P46589; -. DR STRING; 5476.C4YP22; -. DR GeneID; 3642284; -. DR KEGG; cal:CAALFM_C306470WA; -. DR CGD; CAL0000196141; AAF1. DR VEuPathDB; FungiDB:C3_06470W_A; -. DR eggNOG; ENOG502S8GZ; Eukaryota. DR HOGENOM; CLU_527843_0_0_1; -. DR InParanoid; P46589; -. DR OMA; MGISATH; -. DR OrthoDB; 1240218at2759; -. DR Proteomes; UP000000559; Chromosome 3. DR GO; GO:0044406; P:adhesion of symbiont to host; IGI:CGD. DR GO; GO:0007155; P:cell adhesion; IGI:CGD. DR GO; GO:0098609; P:cell-cell adhesion; IDA:CGD. DR GO; GO:0030447; P:filamentous growth; IMP:CGD. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IGI:CGD. PE 4: Predicted; KW Cell adhesion; Reference proteome. FT CHAIN 1..612 FT /note="Adherence factor" FT /id="PRO_0000064451" FT COMPBIAS 64..69 FT /note="Poly-Gln" FT COMPBIAS 100..103 FT /note="Poly-Ser" FT COMPBIAS 117..134 FT /note="Poly-Gln" FT COMPBIAS 269..272 FT /note="Poly-Asn" FT COMPBIAS 517..520 FT /note="Poly-Pro" FT COMPBIAS 579..582 FT /note="Poly-Pro" FT COMPBIAS 596..605 FT /note="Poly-Gln" FT CONFLICT 142 FT /note="F -> N (in Ref. 5; AAA62506)" FT /evidence="ECO:0000305" FT CONFLICT 451 FT /note="T -> I (in Ref. 5; AAA62506)" FT /evidence="ECO:0000305" SQ SEQUENCE 612 AA; 68794 MW; 77B60E45C35C1B23 CRC64; MSSFNSNSNP ANAQNLSSFQ FQPPKEDVIF DTHQMSLSVP QSRYYASSMM QQSQQGQPQS QTSQQQQQQP FLMNIPPAFT QTQPQQMLYA MPPLQTQQPS SSSATTNNVV PPHHYNQQQS QQQQQQQQQY QQMQPQPNNM QFFDNTIPNY LIMNQTISPS QTQTTAQPNI SYYNYSTQPQ LQSAQPISHS QPQPQPQATQ PRSNRSRSQT SFSKPRGSRQ VSGSGRSTGA KKQSAITSGS TGTGPARNAD TGMTSVANST STTTMTTTNN NNKLSVSAPV NVIYANLPER LQQVLPAPPL SRAPVRPDVT VNLTSKRAKR KSKFTPEQDD MIVNLKKKGK SWVEIAEITG VGSYLAARNR FQVIVGQQGN NNSSAWDNTD KLFLNQLLDA GEIEKWRFIC CELNKSTNKN FTDYECREMI RQLFWLNPAS FGVNEETIIE SQKEKKLTEK TIEQREQQRK KRASANHSPP DSDSITNTNN NQQEVKYIDP QYKNYQSQLM PNQNTGSGAT KISSTTPPPP SQALSNNVNT MNKNIVSSAL GGTSFSQEQH SLHSNQHHHN HQQHPLIHHH QYQQQSSLPP PPTIPSTIPT SSLSIQQQQQ QQQQQLYNKQ FY //