ID GTS1_ASCSU STANDARD; PRT; 205 AA. AC P46436; DT 01-NOV-1995 (Rel. 32, Created) DT 01-FEB-1996 (Rel. 33, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE GLUTATHIONE S-TRANSFERASE 1 (EC 2.5.1.18) (GST CLASS-SIGMA). GN GST1. OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides). OC Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; OC Ascarididae; Ascaris. OX NCBI_TaxID=6253; RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 1-40. RX MEDLINE=94239466; PubMed=8183318; RA Liebau E., Schoenberger O.L., Walter R.D., Henkle-Duehrsen K.J.; RT "Molecular cloning and expression of a cDNA encoding glutathione S- RT transferase from Ascaris suum."; RL Mol. Biochem. Parasitol. 63:167-170(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=97307883; PubMed=9182731; RA Liebau E., Eckelt V.H., Wildenburg G., Teesdale-Spittle P., RA Brophy P.M., Walter R.D., Henkle-Duehrsen K.; RT "Structural and functional analysis of a glutathione S-transferase RT from Ascaris suum."; RL Biochem. J. 324:659-666(1997). CC -!- FUNCTION: CONJUGATION OF REDUCED GLUTATHIONE TO A WIDE NUMBER OF CC EXOGENOUS AND ENDOGENOUS HYDROPHOBIC ELECTROPHILES. CAN ALSO CC FUNCTION AS A GSH PEROXIDASE. CC -!- CATALYTIC ACTIVITY: RX + GLUTATHIONE = HX + R-S-GLUTATHIONE. CC -!- SIMILARITY: BELONGS TO THE GST SUPERFAMILY. SIGMA FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X75502; CAA53218.1; -. DR EMBL; Y10613; CAA71620.1; -. DR HSSP; P24472; 1GUK. DR INTERPRO; IPR000521; -. DR PFAM; PF00043; GST; 1. KW Transferase. FT INIT_MET 0 0 SQ SEQUENCE 205 AA; 23454 MW; 2478E424E8AD14B1 CRC64; PQYKLTYFDI RGLGEGARLI FHQAGVKFED NRLKREDWPA LKPKTPFGQL PLLEVDGEVL AQSAAIYRYL GRQFGLAGKT PMEEAQVDSI FDQFKDFMAE LRPCFRVLAG FEEGDKEKVL KEVAVPARDK HLPLLEKFLA KSGSEYMVGK SVTWADLVIT DSLASWESLI PDFLSGHLQL KKYIEHVREL PNIKKWIAER PKTPY //