ID GST1_ASCSU STANDARD; PRT; 205 AA. AC P46436; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 07-FEB-2006, entry version 27. DE Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma). GN Name=GST1; OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides). OC Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; OC Ascarididae; Ascaris. OX NCBI_TaxID=6253; RN [1] RP NUCLEOTIDE SEQUENCE, AND PROTEIN SEQUENCE OF 1-40. RX MEDLINE=94239466; PubMed=8183318; DOI=10.1016/0166-6851(94)90021-3; RA Liebau E., Schoenberger O.L., Walter R.D., Henkle-Duehrsen K.J.; RT "Molecular cloning and expression of a cDNA encoding glutathione S- RT transferase from Ascaris suum."; RL Mol. Biochem. Parasitol. 63:167-170(1994). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97307883; PubMed=9182731; RA Liebau E., Eckelt V.H., Wildenburg G., Teesdale-Spittle P., RA Brophy P.M., Walter R.D., Henkle-Duehrsen K.; RT "Structural and functional analysis of a glutathione S-transferase RT from Ascaris suum."; RL Biochem. J. 324:659-666(1997). CC -!- FUNCTION: Conjugation of reduced glutathione to a wide number of CC exogenous and endogenous hydrophobic electrophiles. Can also CC function as a GSH peroxidase. CC -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione. CC -!- SIMILARITY: Belongs to the GST superfamily. Sigma family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X75502; CAA53218.1; -; mRNA. DR EMBL; Y10613; CAA71620.1; -; Genomic_DNA. DR PIR; S38626; S38626. DR HSSP; O60760; 1IYH. DR GO; GO:0004364; F:glutathione transferase activity; NAS. DR InterPro; IPR004046; GST_Cterm. DR InterPro; IPR004045; GST_Nterm. DR InterPro; IPR012336; Thioredoxin-like. DR InterPro; IPR012335; Thioredoxin_fold. DR Pfam; PF00043; GST_C; 1. DR Pfam; PF02798; GST_N; 1. KW Direct protein sequencing; Transferase. FT INIT_MET 0 0 FT CHAIN 1 205 Glutathione S-transferase 1. FT /FTId=PRO_0000185922. SQ SEQUENCE 205 AA; 23454 MW; 2478E424E8AD14B1 CRC64; PQYKLTYFDI RGLGEGARLI FHQAGVKFED NRLKREDWPA LKPKTPFGQL PLLEVDGEVL AQSAAIYRYL GRQFGLAGKT PMEEAQVDSI FDQFKDFMAE LRPCFRVLAG FEEGDKEKVL KEVAVPARDK HLPLLEKFLA KSGSEYMVGK SVTWADLVIT DSLASWESLI PDFLSGHLQL KKYIEHVREL PNIKKWIAER PKTPY //