ID GC20_YEAST STANDARD; PRT; 752 AA. AC P43535; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 01-NOV-1995 (Rel. 32, Last annotation update) DE GCN20 PROTEIN. GN GCN20 OR YFR009W. OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycetes; Saccharomycetales; OC Saccharomycetaceae; Saccharomyces. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95347344. RA Vazquez de Aldana C.R., Marton M.J., Hinnebusch A.G.; RT "GCN20, a novel ATP binding cassette protein, and GCN1 reside in a RT complex that mediates activation of the eIF-2 alpha kinase GCN2 in RT amino acid-starved cells."; RL EMBO J. 14:3184-3199(1995). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288C / AB972; RX MEDLINE; 95400292. RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., RA Sasanuma S.-I., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., RA Yamazaki M., Tashiro H., Eki T.; RT "Analysis of the nucleotide sequence of chromosome VI from RT Saccharomyces cerevisiae."; RL Nat. Genet. 10:261-268(1995). CC -!- FUNCTION: POSITIVE EFFECTOR OF THE EIF-2-ALPHA KINASE ACTIVITY OF CC GCN2. CC -!- SUBUNIT: COMPONENT OF A HETEROMERIC COMPLEX THAT INCLUDES GCN1 AND CC GCN20. CC -!- SIMILARITY: BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY CC (ABC TRANSPORTERS). EF-3 SUBFAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U19971; AAA75444.1; -. DR EMBL; D50617; BAA09248.1; -. DR SGD; L0000689; GCN20. DR INTERPRO; IPR001617; -. DR PFAM; PF00005; ABC_tran; 2. DR PROSITE; PS00211; ABC_TRANSPORTER; 1. KW ATP-binding; Repeat. FT NP_BIND 232 239 ATP (POTENTIAL). FT NP_BIND 565 572 ATP (POTENTIAL). SQ SEQUENCE 752 AA; 85027 MW; 486FED10305A572E CRC64; MASIGSQVRK AASSIDPIVT DYAVGYFNHL SGITFDAVQS KQVDLSTEVQ FVSDLLIDAG ASKAKVKELS ESILKQLTTQ LKENEAKLEL TGDTSKRLLD INVLKSHNSK SDINVSLSML GVNGDIEHTG RKMETRVDLK KLAKAEQKIA KKVAKRNNKF VKYEASKLIN DQKEEDYDSF FLQINPLEFG SSAGKSKDIH IDTFDLYVGD GQRILSNAQL TLSFGHRYGL VGQNGIGKST LLRALSRREL NVPKHVSILH VEQELRGDDT KALQSVLDAD VWRKQLLSEE AKINERLKEM DVLRQEFEED SLEVKKLDNE REDLDNHLIQ ISDKLVDMES DKAEARAASI LYGLGFSTEA QQQPTNSFSG GWRMRLSLAR ALFCQPDLLL LDEPSNMLDV PSIAYLAEYL KTYPNTVLTV SHDRAFLNEV ATDIIYQHNE RLDYYRGQDF DTFYTTKEER RKNAQREYDN QMVYRKHLQE FIDKYRYNAA KSQEAQSRIK KLEKLPVLEP PEQDKTIDFK FPECDKLSPP IIQLQDVSFG YDENNLLLKD VNLDVQMDSR IALVGANGCG KTTLLKIMME QLRPLKGFVS RNPRLRIGYF TQHHVDSMDL TTSAVDWMSK SFPGKTDEEY RRHLGSFGIT GTLGLQKMQL LSGGQKSRVA FAALCLNNPH ILVLDEPSNH LDTTGLDALV EALKNFNGGV LMVSHDISVI DSVCKEIWVS EQGTVKRFEG TIYDYRDYIL QSADAAGVVK KH //