ID CYAA_ANACY STANDARD; PRT; 502 AA. AC P43524; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl DE cyclase). GN CYA. OS Anabaena cylindrica. OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Anabaena. OX NCBI_TaxID=1165; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=IAM M-1; RX MEDLINE=95325334; PubMed=7601856; RA Katayama M., Wada Y., Ohmori M.; RT "Molecular cloning of the cyanobacterial adenylate cyclase gene from RT the filamentous cyanobacterium Anabaena cylindrica."; RL J. Bacteriol. 177:3873-3878(1995). CC -!- FUNCTION: May function as a membrane-localized receptor protein. CC -!- CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. CC -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity). CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Thylakoid CC membrane. CC -!- DOMAIN: The amino-terminal half could sense signals such as pH or CC a change in membrane potential and regulates the catalytic CC activity of the carboxy-terminal half. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family. CC -!- SIMILARITY: Contains 1 HAMP domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D55650; BAA09511.1; -. DR PIR; I39600; I39600. DR HSSP; Q02846; 1AWL. DR InterPro; IPR001054; G_cyclase. DR InterPro; IPR003660; HAMP. DR Pfam; PF00211; Guanylate_cyc; 1. DR Pfam; PF00672; HAMP; 1. DR SMART; SM00044; CYCc; 1. DR SMART; SM00304; HAMP; 1. DR PROSITE; PS50125; GUANYLATE_CYCLASES_2; 1. DR PROSITE; PS50885; HAMP; 1. KW Lyase; cAMP biosynthesis; Transmembrane; Thylakoid; Metal-binding; KW Magnesium. FT DOMAIN 1 25 Cytoplasmic (Potential). FT TRANSMEM 26 46 Potential. FT DOMAIN 47 203 LUMENAL, THYLAKOID (POTENTIAL). FT TRANSMEM 204 226 Potential. FT DOMAIN 227 502 Cytoplasmic (Potential). FT DOMAIN 227 280 HAMP. FT DOMAIN 321 502 Catalytic. FT METAL 325 325 Magnesium (By similarity). FT METAL 369 369 Magnesium (By similarity). SQ SEQUENCE 502 AA; 55293 MW; C61023B37CD8C4E9 CRC64; MGDFCRRVDC KAMKFFALRS SIRTQIMAST TLLILALIGA IVTVWAKSES TLYHQEKLND AKILSKVLSS TYANEVSEEN WSQIRLNIDL LLRENEDFLY ALVSDSNQKN QIAASSPDEF QNNYIPDIVS LSVTNAAINS SEKTHVVETF ILRDIYFADK LRAKRGEKVM EVSSDIQTLS GRKLGKLRIG ISLRKVNLAV TNAVNQALVV GFAGLNIGWI CAYFLAQHLS DPVRRLQISV AKIAGGDLQH RADIHSRADE IGALATSVNE MSAALQISFN KLKKTLDSFE RFVPNKFISV IAPQGIENIE VGAASTRRMT ILFCDIRGYT SMSEAMEPIE IFRFLNDYLA CMGKAIDEAG GFIDKYIGDA IMALFDDGNT DCALHAAILM QQALDKFNDE RSMQTGKTGL PRISVGIGIH RGTVVMGTVG FTSRIDSTVI GDAVNVASRI EGLTKQYGCN ILITESVVRN LSCPESFSLR LIDKSVKVKG KDEAISIYEV KA //