ID RDGB_DROME Reviewed; 1259 AA. AC P43125; O02434; Q6NP01; Q961R2; Q9VY88; DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2005, sequence version 2. DT 31-OCT-2006, entry version 46. DE Protein retinal degeneration B (Probable calcium transporter rdgB). GN Name=rdgB; ORFNames=CG11111; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, AND TISSUE RP SPECIFICITY. RC STRAIN=Oregon-R; TISSUE=Head; RX MEDLINE=91231170; PubMed=1903119; RA Vihtelic T.S., Hyde D.R., O'Tousa J.E.; RT "Isolation and characterization of the Drosophila retinal degeneration RT B (rdgB) gene."; RL Genetics 127:761-768(1991). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). RX MEDLINE=98343889; PubMed=9680295; RA Rubboli F., Bulfone A., Bogni S., Marchitiello A., Zollo M., RA Borsani G., Ballabio A., Banfi S.; RT "A mammalian homologue of the Drosophila retinal degeneration B gene: RT implications for the evolution of phototransduction mechanisms."; RL Genes Funct. 1:205-213(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [4] RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). RC STRAIN=Berkeley; TISSUE=Head; RX MEDLINE=22426066; PubMed=12537569; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., RA Rubin G.M., Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 513-1241. RC STRAIN=Berkeley; TISSUE=Head; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.E.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May control phosphatidylinositol concentration in CC transport vesicles from the subrhabdomeric cisternae (SRC) to the CC rhabdomere. May function as a calcium transporter. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=A; CC IsoId=P43125-1; Sequence=Displayed; CC Note=No experimental confirmation available; CC Name=B; CC IsoId=P43125-2; Sequence=VSP_014533; CC -!- TISSUE SPECIFICITY: Expressed in adult heads, not detected in CC bodies. CC -!- MISCELLANEOUS: Flies lacking rdgB exhibit rapid light-induced CC retinal degeneration. CC -!- SIMILARITY: Belongs to the rdgB family. CC -!- SIMILARITY: Contains 1 DDHD domain. CC -!- CAUTION: Ref.1 sequence differs from that shown due to frameshifts CC in positions 1054 and 1158. CC -!- CAUTION: Ref.6 sequence differs from that shown due to intron CC retention. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X57978; CAA41044.1; ALT_FRAME; mRNA. DR EMBL; Y08035; CAA69291.1; -; mRNA. DR EMBL; AE014298; AAF48315.1; -; Genomic_DNA. DR EMBL; AE014298; AAF48316.2; -; Genomic_DNA. DR EMBL; AY051422; AAK92846.1; -; mRNA. DR EMBL; BT011130; AAR82797.1; ALT_SEQ; mRNA. DR PIR; A61221; A61221. DR UniGene; Dm.7839; -. DR HSSP; P53810; 1KCM. DR Ensembl; CG11111; Drosophila melanogaster. DR KEGG; dme:CG11111-PA; -. DR KEGG; dme:CG11111-PB; -. DR FlyBase; FBgn0003218; rdgB. DR GO; GO:0016021; C:integral to membrane; TAS:FlyBase. DR GO; GO:0016029; C:subrhabdomeral cisterna; TAS:FlyBase. DR GO; GO:0008525; F:phosphatidylcholine transporter activity; IDA:FlyBase. DR GO; GO:0008526; F:phosphatidylinositol transporter activity; IDA:FlyBase. DR GO; GO:0016059; P:deactivation of rhodopsin mediated signaling; IMP:FlyBase. DR GO; GO:0030384; P:phosphoinositide metabolism; IMP:FlyBase. DR GO; GO:0007602; P:phototransduction; TAS:FlyBase. DR GO; GO:0016056; P:rhodopsin mediated signaling; IMP:FlyBase. DR GO; GO:0007608; P:sensory perception of smell; IMP:FlyBase. DR InterPro; IPR004177; DDHD. DR InterPro; IPR013209; LNS2. DR InterPro; IPR001666; PI_transfer. DR PANTHER; PTHR10658; PI_transfer; 1. DR Pfam; PF02862; DDHD; 1. DR Pfam; PF02121; IP_trans; 1. DR Pfam; PF08235; LNS2; 1. DR PRINTS; PR00391; PITRANSFER. DR SMART; SM00775; LNS2; 1. DR PROSITE; PS51043; DDHD; 1. KW Alternative splicing; Calcium; Calcium transport; Complete proteome; KW Ion transport; Sensory transduction; Transport; Vision. FT CHAIN 1 1259 Protein retinal degeneration B. FT /FTId=PRO_0000097209. FT DOMAIN 730 913 DDHD. FT COMPBIAS 321 332 Asp/Glu-rich (highly acidic). FT VAR_SEQ 1242 1259 YLERKTVSSCCLMVFQTT -> LHEQATNEN (in FT isoform B). FT /FTId=VSP_014533. FT CONFLICT 89 91 WNA -> MEC (in Ref. 1). FT CONFLICT 542 543 QH -> HD (in Ref. 1). FT CONFLICT 622 622 Y -> C (in Ref. 1). FT CONFLICT 824 824 H -> R (in Ref. 1). FT CONFLICT 1002 1002 E -> Q (in Ref. 1). SQ SEQUENCE 1259 AA; 138895 MW; 9DD40B76EB1079F7 CRC64; MLIKEYRIPL PLTVEEYRIA QLYMIAKKSR EESHGEGSGV EIIINEPYKD GPGGNGQYTK KIYHVGNHLP GWIKSLLPKS ALTVEEEAWN AYPYTRTRYT CPFVEKFSLD IETYYYPDNG YQDNVFQLSG SDLRNRIVDV IDIVKDQLWG GDYVKEEDPK HFVSDKTGRG PLAEDWLEEY WREVKGKKQP TPRNMSLMTA YKICRVEFRY WGMQTKLEKF IHDVALRKMM LRAHRQAWAW QDEWFGLTIE DIRELERQTQ LALAKKMGGG EECSDDSVSE PYVSTAATAA STTGSERKKS APAVPPIVTQ QPPSAEASSD EEGEEEEDDD EDENDAIGTG VDLSANQGGS AQRSRSQSIQ MAQKGKFGSK GALHSPVGSA HSFDLQVANW RMERLEVDSK SNSDEEFFDC LDTNETNSLA KWSSLELLGE GDDSPPPHGG PSSAASVGGR GNSRQEDSIF NQDFLMRVAS ERGNKRQLRS SASVDRSHDS SPPGSPSTPS CPTTILILVV HAGSVLDAAS ELTAKKSDVT TFRGSFEAVM RQHYPSLLTH VTIKMVPCPS ICTDALGILS SLSPYSFDAS PSAADIPNIA DVPIGAIPLL SVASPEFHET VNKTVAAANI VYHEFLKSEE GHGFSGQIVM LGDSMGSLLA YEALCRSNGS QPGTASGASN SGGDAATNIN THNPLSPRNS RLDDDERFIE ADLDAKRLLV APSPRRRRSS SSSDSRATKL DFEVCDFFMF GSPLSVVLAA RKLHDAKAAL PRPNCHQVYN LFHPTDPIAS RLEPLLSARF SILAPVNVPR YAKYPLGNGQ PLHLLEVIQS HPQHFNDGNN LLAGRRLSDA SMQSTISGLI ENVSLSTIHA LQNKWWGTKR LDYALYCPEG LSNFPAHALP HLFHASYWES PDVIAFILRQ IGKFEGIPFV GSNDDKDNAS FHPGQPREKW IKKRTSVKLK NVAANHRAND VIVQEGREQR LNARFMYGPL DMITLHGEKV DVHIMKDPPA GEWTFLSTEV TDKNGRISYS IPDQVSLGYG IYPVKMVVRG DHTSVDCYMA VVPPLTECVV FSIDGSFTAS MSVTGRDPKV RAGAVDVCRH WQELGYLLIY ITGRPDMQQQ RVVSWLSQHN FPHGLISFAD GLSTDPLGHK TAYLNNLVQN HGISITAAYG SSKDISVYTN VGMRTDQIFI VGKVGKKLQS NATVLSDGYA AHLAGLQAVG GSRPAKGNAR MVIPRGCFNL PGQTANPRRR RYLERKTVSS CCLMVFQTT //