ID   RDGB_DROME     STANDARD;      PRT;  1259 AA.
AC   P43125; O02434; Q6NP01; Q961R2; Q9VY88;
DT   01-NOV-1995 (Rel. 32, Created)
DT   13-SEP-2005 (Rel. 48, Last sequence update)
DT   13-SEP-2005 (Rel. 48, Last annotation update)
DE   Retinal degeneration B protein (Probable calcium transporter rdgB).
GN   Name=rdgB; ORFNames=CG11111;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, AND TISSUE
RP   SPECIFICITY.
RC   STRAIN=Oregon-R; TISSUE=Head;
RX   MEDLINE=91231170; PubMed=1903119;
RA   Vihtelic T.S., Hyde D.R., O'Tousa J.E.;
RT   "Isolation and characterization of the Drosophila retinal degeneration
RT   B (rdgB) gene.";
RL   Genetics 127:761-768(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RX   PubMed=9680295;
RA   Rubboli F., Bulfone A., Bogni S., Marchitiello A., Zollo M.,
RA   Borsani G., Ballabio A., Banfi S.;
RT   "A mammalian homologue of the Drosophila retinal degeneration B gene:
RT   implications for the evolution of phototransduction mechanisms.";
RL   Genes Funct. 1:205-213(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   STRAIN=Berkeley; TISSUE=Head;
RX   MEDLINE=22426066; PubMed=12537569;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 513-1241.
RC   STRAIN=Berkeley; TISSUE=Head;
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA   Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA   Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA   Celniker S.E.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May control phosphatidylinositol concentration in
CC       transport vesicles from the subrhabdomeric cisternae (SRC) to the
CC       rhabdomere. May function as a calcium transporter.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P43125-1; Sequence=Displayed;
CC         Note=No experimental confirmation available;
CC       Name=B;
CC         IsoId=P43125-2; Sequence=VSP_014533;
CC   -!- TISSUE SPECIFICITY: Expressed in adult heads, not detected in
CC       bodies.
CC   -!- MISCELLANEOUS: Flies lacking rdgB exhibit rapid light-induced
CC       retinal degeneration.
CC   -!- SIMILARITY: Contains 1 DDHD domain.
CC   -!- CAUTION: Ref.1 sequence differs from that shown due to frameshifts
CC       in positions 1054 and 1158.
CC   -!- CAUTION: Ref.6 sequence differs from that shown due to intron
CC       retention.
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DR   EMBL; X57978; CAA41044.1; ALT_FRAME; mRNA.
DR   EMBL; Y08035; CAA69291.1; -; mRNA.
DR   EMBL; AE003493; AAF48315.1; -; Genomic_DNA.
DR   EMBL; AE003493; AAF48316.2; -; Genomic_DNA.
DR   EMBL; AY051422; AAK92846.1; -; mRNA.
DR   EMBL; BT011130; AAR82797.1; ALT_SEQ; mRNA.
DR   PIR; A61221; A61221.
DR   HSSP; P53810; 1KCM.
DR   Ensembl; CG11111; Drosophila melanogaster.
DR   FlyBase; FBgn0003218; rdgB.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   GO; GO:0016029; C:subrhabdomeral cisterna; NAS.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IDA.
DR   GO; GO:0008526; F:phosphatidylinositol transporter activity; IDA.
DR   GO; GO:0016059; P:deactivation of rhodopsin mediated signaling; IMP.
DR   GO; GO:0007608; P:perception of smell; IMP.
DR   GO; GO:0007602; P:phototransduction; TAS.
DR   GO; GO:0016056; P:rhodopsin mediated signaling; IMP.
DR   InterPro; IPR004177; DDHD.
DR   InterPro; IPR001666; PI_transfer.
DR   Pfam; PF02862; DDHD; 1.
DR   Pfam; PF02121; IP_trans; 1.
DR   PRINTS; PR00391; PITRANSFER.
DR   PROSITE; PS51043; DDHD; 1.
KW   Alternative splicing; Calcium; Calcium transport; Glycoprotein;
KW   Ion transport; Sensory transduction; Transport; Vision.
FT   DOMAIN      730    913       DDHD.
FT   COMPBIAS    321    332       Asp/Glu-rich (highly acidic).
FT   CARBOHYD    194    194       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    414    414       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    612    612       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    658    658       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    852    852       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    928    928       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD   1191   1191       N-linked (GlcNAc...) (Potential).
FT   VARSPLIC   1242   1259       YLERKTVSSCCLMVFQTT -> LHEQATNEN (in
FT                                isoform B).
FT                                /FTId=VSP_014533.
FT   CONFLICT     89     91       WNA -> MEC (in Ref. 1).
FT   CONFLICT    542    543       QH -> HD (in Ref. 1).
FT   CONFLICT    622    622       Y -> C (in Ref. 1).
FT   CONFLICT    824    824       H -> R (in Ref. 1).
FT   CONFLICT   1002   1002       E -> Q (in Ref. 1).
SQ   SEQUENCE   1259 AA;  138895 MW;  9DD40B76EB1079F7 CRC64;
     MLIKEYRIPL PLTVEEYRIA QLYMIAKKSR EESHGEGSGV EIIINEPYKD GPGGNGQYTK
     KIYHVGNHLP GWIKSLLPKS ALTVEEEAWN AYPYTRTRYT CPFVEKFSLD IETYYYPDNG
     YQDNVFQLSG SDLRNRIVDV IDIVKDQLWG GDYVKEEDPK HFVSDKTGRG PLAEDWLEEY
     WREVKGKKQP TPRNMSLMTA YKICRVEFRY WGMQTKLEKF IHDVALRKMM LRAHRQAWAW
     QDEWFGLTIE DIRELERQTQ LALAKKMGGG EECSDDSVSE PYVSTAATAA STTGSERKKS
     APAVPPIVTQ QPPSAEASSD EEGEEEEDDD EDENDAIGTG VDLSANQGGS AQRSRSQSIQ
     MAQKGKFGSK GALHSPVGSA HSFDLQVANW RMERLEVDSK SNSDEEFFDC LDTNETNSLA
     KWSSLELLGE GDDSPPPHGG PSSAASVGGR GNSRQEDSIF NQDFLMRVAS ERGNKRQLRS
     SASVDRSHDS SPPGSPSTPS CPTTILILVV HAGSVLDAAS ELTAKKSDVT TFRGSFEAVM
     RQHYPSLLTH VTIKMVPCPS ICTDALGILS SLSPYSFDAS PSAADIPNIA DVPIGAIPLL
     SVASPEFHET VNKTVAAANI VYHEFLKSEE GHGFSGQIVM LGDSMGSLLA YEALCRSNGS
     QPGTASGASN SGGDAATNIN THNPLSPRNS RLDDDERFIE ADLDAKRLLV APSPRRRRSS
     SSSDSRATKL DFEVCDFFMF GSPLSVVLAA RKLHDAKAAL PRPNCHQVYN LFHPTDPIAS
     RLEPLLSARF SILAPVNVPR YAKYPLGNGQ PLHLLEVIQS HPQHFNDGNN LLAGRRLSDA
     SMQSTISGLI ENVSLSTIHA LQNKWWGTKR LDYALYCPEG LSNFPAHALP HLFHASYWES
     PDVIAFILRQ IGKFEGIPFV GSNDDKDNAS FHPGQPREKW IKKRTSVKLK NVAANHRAND
     VIVQEGREQR LNARFMYGPL DMITLHGEKV DVHIMKDPPA GEWTFLSTEV TDKNGRISYS
     IPDQVSLGYG IYPVKMVVRG DHTSVDCYMA VVPPLTECVV FSIDGSFTAS MSVTGRDPKV
     RAGAVDVCRH WQELGYLLIY ITGRPDMQQQ RVVSWLSQHN FPHGLISFAD GLSTDPLGHK
     TAYLNNLVQN HGISITAAYG SSKDISVYTN VGMRTDQIFI VGKVGKKLQS NATVLSDGYA
     AHLAGLQAVG GSRPAKGNAR MVIPRGCFNL PGQTANPRRR RYLERKTVSS CCLMVFQTT
//