ID   PHR1_CANAL              Reviewed;         548 AA.
AC   P43076; Q5A661;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 3.
DT   03-OCT-2012, entry version 70.
DE   RecName: Full=pH-responsive protein 1;
DE   AltName: Full=pH-regulated protein 1;
DE   Flags: Precursor;
GN   Name=PHR1; ORFNames=CaO19.11310, CaO19.3829;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales;
OC   Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   MEDLINE=95124318; PubMed=7823929;
RA   Saporito-Irwin S.M., Birse C.E., Sypherd P.S., Fonzi W.A.;
RT   "PHR1, a pH-regulated gene of Candida albicans, is required for
RT   morphogenesis.";
RL   Mol. Cell. Biol. 15:601-613(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
CC   -!- FUNCTION: Required for apical cell growth and plays an essential
CC       role in morphogenesis. May be integral to the pathogenic ability
CC       of the organism.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor
CC       (Potential).
CC   -!- INDUCTION: Strongly expressed under conditions of alkaline pH but
CC       not expressed at any pH below 5.5.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 72 family.
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DR   EMBL; M90812; AAA68196.1; -; Genomic_DNA.
DR   EMBL; AACQ01000057; EAK98260.1; -; Genomic_DNA.
DR   EMBL; AACQ01000056; EAK98337.1; -; Genomic_DNA.
DR   RefSeq; XP_717233.1; XM_712140.1.
DR   RefSeq; XP_717309.1; XM_712216.1.
DR   ProteinModelPortal; P43076; -.
DR   CAZy; CBM43; Carbohydrate-Binding Module Family 43.
DR   CAZy; GH72; Glycoside Hydrolase Family 72.
DR   GeneID; 3641088; -.
DR   GeneID; 3641108; -.
DR   KEGG; cal:CaO19.11310; -.
DR   KEGG; cal:CaO19.3829; -.
DR   CGD; CAL0002002; PHR1.
DR   eggNOG; NOG73259; -.
DR   GO; GO:0046658; C:anchored to plasma membrane; IDA:CGD.
DR   GO; GO:0030428; C:cell septum; IDA:CGD.
DR   GO; GO:0009986; C:cell surface; IDA:CGD.
DR   GO; GO:0033101; C:cellular bud membrane; IDA:CGD.
DR   GO; GO:0005621; C:cellular bud scar; IDA:CGD.
DR   GO; GO:0005576; C:extracellular region; IDA:CGD.
DR   GO; GO:0030446; C:hyphal cell wall; IDA:CGD.
DR   GO; GO:0045121; C:membrane raft; IDA:CGD.
DR   GO; GO:0030445; C:yeast-form cell wall; IDA:CGD.
DR   GO; GO:0043169; F:cation binding; IEA:InterPro.
DR   GO; GO:0042123; F:glucanosyltransferase activity; IDA:CGD.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; ISS:CGD.
DR   GO; GO:0051825; P:adhesion to other organism involved in symbiotic interaction; IMP:CGD.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0031589; P:cell-substrate adhesion; IMP:CGD.
DR   GO; GO:0035690; P:cellular response to drug; IMP:CGD.
DR   GO; GO:0071467; P:cellular response to pH; IMP:CGD.
DR   GO; GO:0044114; P:development of symbiont in host; IMP:CGD.
DR   GO; GO:0044409; P:entry into host; IMP:CGD.
DR   GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR   GO; GO:0031505; P:fungal-type cell wall organization; IDA:CGD.
DR   GO; GO:0044117; P:growth of symbiont in host; IMP:CGD.
DR   GO; GO:0009405; P:pathogenesis; IMP:CGD.
DR   Gene3D; G3DSA:3.20.20.80; Glyco_hydro_cat; 1.
DR   InterPro; IPR004886; Glucanosyltransferase.
DR   InterPro; IPR013781; Glyco_hydro_catalytic_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR012946; X8.
DR   Pfam; PF03198; Glyco_hydro_72; 1.
DR   Pfam; PF07983; X8; 1.
DR   SMART; SM00768; X8; 1.
DR   SUPFAM; SSF51445; Glyco_hydro_cat; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Glycoprotein; GPI-anchor;
KW   Lipoprotein; Membrane; Reference proteome; Signal.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    517       pH-responsive protein 1.
FT                                /FTId=PRO_0000010483.
FT   PROPEP      518    548       Removed in mature form (Potential).
FT                                /FTId=PRO_0000010484.
FT   COMPBIAS    453    499       Ser-rich.
FT   COMPBIAS    500    517       Poly-Ser.
FT   LIPID       517    517       GPI-anchor amidated serine (Potential).
FT   CARBOHYD     41     41       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    173    173       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    261    261       N-linked (GlcNAc...) (Potential).
FT   CONFLICT      9      9       V -> A (in Ref. 1; AAA68196).
FT   CONFLICT     79     79       A -> R (in Ref. 1; AAA68196).
FT   CONFLICT    501    501       T -> A (in Ref. 1; AAA68196).
SQ   SEQUENCE   548 AA;  59515 MW;  0836B7A293FAB3CC CRC64;
     MYSLIKSLVT FATLFSLTLA KFESSTPPVE VVGNKFYFSN NGSQFLIRGI AYQQDAAGSV
     SSGYDADPNR KYNDPLADAD ACKRDVKYFK ESNTNTLRVY AIDPDKDHEE CMKIFSDAGI
     YIVADLSEPT VSINRNNPEW NLDLYKRYTK VIDKMQEYSN VLGFFAGNEV TNNRSNTDAS
     AFVKAAIRDM KKYIKESDYR QIPVGYSSND DEEIRVAIAD YFSCGSLDDR ADFFGINMYE
     WCGKSTFETS GYKDRTEEIK NLTIPAFFSE YGCNANRPRL FQEIGTLYSD KMTDVWSGGI
     VYMYFEEANK YGLVSVDGNS VKTLSDYNNY KSEMNKISPS LAHTSTLSSS DASKTLQCPG
     TAASTWKAAT NLPPTPDESY CDCISKSLEC VVADDVDKED YGDLFGQVCG YIDCSAISAD
     GSKGEYGVAS FCSDKDRLSY VLNQYYLDQD KKSSACDFKG SASINSKASA SGSCKAVSGV
     ATGKASSSGG SSKSGSSSAS TSGSSSSSTS SGSSSSSGVK ATQQMSMVKL VSIITIVTAF
     VGGMSVVF
//