ID   RS27_HUMAN     STANDARD;      PRT;    83 AA.
AC   P42677;
DT   01-NOV-1995 (Rel. 32, Created)
DT   01-NOV-1995 (Rel. 32, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   40S ribosomal protein S27 (Metallopan-stimulin 1) (MPS-1).
GN   Name=RPS27; Synonyms=MPS1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mammary carcinoma;
RX   MEDLINE=94012671; PubMed=8407955;
RA   Fernandez-Pol J.A., Klos D.J., Hamilton P.D.;
RT   "A growth factor-inducible gene encodes a novel nuclear protein with
RT   zinc finger structure.";
RL   J. Biol. Chem. 268:21198-21204(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Heart;
RX   MEDLINE=97064822; PubMed=8908372;
RA   Tsui S.K.W., Lee S.M.Y., Fung K.P., Waye M.M.Y., Lee C.Y.;
RT   "Primary structures and sequence analysis of human ribosomal proteins
RT   L39 and S27.";
RL   Biochem. Mol. Biol. Int. 40:611-616(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21864036; PubMed=11875025; DOI=10.1101/gr.214202;
RA   Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S.,
RA   Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.;
RT   "The human ribosomal protein genes: sequencing and comparative
RT   analysis of 73 genes.";
RL   Genome Res. 12:379-390(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Uterus;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [5]
RP   PROTEIN SEQUENCE OF 1-10.
RX   PubMed=8706699;
RA   Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K.,
RA   Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.;
RT   "Characterization of the human small-ribosomal-subunit proteins by N-
RT   terminal and internal sequencing, and mass spectrometry.";
RL   Eur. J. Biochem. 239:144-149(1996).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 5-73.
RX   MEDLINE=98248690; PubMed=9582194;
RA   Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N.,
RA   Hudson T.J., Tanaka T., Page D.C.;
RT   "A map of 75 human ribosomal protein genes.";
RL   Genome Res. 8:509-523(1998).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in a wide variety of actively
CC       proliferating cells and tumor tissues.
CC   -!- SIMILARITY: Belongs to the ribosomal protein S27e family.
CC   -!- CAUTION: Was originally (Ref.1) thought to be a protein that could
CC       have played a role as a potentially important mediator of cellular
CC       proliferative responses to various growth factors and other
CC       environmental signals. Capable of specific binding to a cAMP
CC       response element in DNA.
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DR   EMBL; L19739; AAA59867.1; -.
DR   EMBL; U57847; AAB02266.1; -.
DR   EMBL; AB061845; BAB79483.1; -.
DR   EMBL; BC002658; AAH02658.1; -.
DR   EMBL; AB007162; BAA25825.1; -.
DR   PIR; A48045; A48045.
DR   IntAct; P42677; -.
DR   Genew; HGNC:10416; RPS27.
DR   H-InvDB; HIX0001098; -.
DR   Reactome; P42677; -.
DR   MIM; 603702; -.
DR   GO; GO:0005843; C:cytosolic small ribosomal subunit (sensu Eu...; TAS.
DR   GO; GO:0003723; F:RNA binding; TAS.
DR   GO; GO:0003735; F:structural constituent of ribosome; TAS.
DR   GO; GO:0008270; F:zinc ion binding; TAS.
DR   GO; GO:0008283; P:cell proliferation; TAS.
DR   GO; GO:0006412; P:protein biosynthesis; TAS.
DR   GO; GO:0007165; P:signal transduction; TAS.
DR   InterPro; IPR000592; Ribosomal_S27E.
DR   Pfam; PF01667; Ribosomal_S27e; 1.
DR   ProDom; PD004466; Ribosomal_S27E; 1.
DR   PROSITE; PS01168; RIBOSOMAL_S27E; 1.
KW   Direct protein sequencing; Metal-binding; Ribosomal protein; Zinc;
KW   Zinc-finger.
FT   INIT_MET      0      0
FT   ZN_FING      36     58       C4-type.
FT   CONFLICT      4      4       K -> R (in Ref. 5).
SQ   SEQUENCE   83 AA;  9330 MW;  FDB14418630BC7CF CRC64;
     PLAKDLLHPS PEEEKRKHKK KRLVQSPNSY FMDVKCPGCY KITTVFSHAQ TVVLCVGCST
     VLCQPTGGKA RLTEGCSFRR KQH
//