ID PBX1_MOUSE STANDARD; PRT; 347 AA. AC P41778; DT 01-NOV-1995 (Rel. 32, Created) DT 01-NOV-1995 (Rel. 32, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN PBX1). GN PBX1 OR PBX-1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=ADRENAL GLAND; RX MEDLINE; 94308119. RA Kagawa N., Ogo A., Takahashi Y., Iwamatsu A., Waterman M.R.; RT "A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for RT the homeodomain protein Pbx1."; RL J. Biol. Chem. 269:18716-18719(1994). CC -!- FUNCTION: PLAYS A ROLE IN THE CAMP-DEPENDENT REGULATION OF CYP17 CC GENE EXPRESSION VIA ITS CAMP-REGULATORY SEQUENCE (CRS1) CC 5'-ATCAATCAA-3'. PROBABLE POSITIVE TRANSCRIPTION REGULATOR. MAY CC HAVE A ROLE IN STEROIDOGENESIS AND SUBSEQUENTLY SEXUAL CC DEVELOPMENT AND DIFFERENTIATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- ALTERNATIVE PRODUCTS: TWO ISOFORMS ARE PRODUCED BY ALTERNATIVE CC SPLICING. CC -!- TISSUE SPECIFICITY: WIDELY DISTRIBUTED IN STEROIDOGENIC AND NON- CC STEROIDOGENIC CELLS. CC -!- SIMILARITY: BELONGS TO THE TALE/PBX FAMILY OF HOMEOBOX PROTEINS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L27453; AAA21832.1; -. DR HSSP; P01366; 1AKH. DR TRANSFAC; T02088; -. DR MGD; MGI:97495; PBX1. DR INTERPRO; IPR000047; -. DR INTERPRO; IPR001356; -. DR PFAM; PF00046; homeobox; 1. DR PRINTS; PR00031; HTHREPRESSR. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Transcription regulation; DNA-binding; Nuclear protein; Activator; KW Homeobox; Alternative splicing; Steroidogenesis; KW Sexual differentiation. FT DOMAIN 127 135 POLY-ALA. FT DNA_BIND 233 295 HOMEOBOX (TALE-TYPE). SQ SEQUENCE 347 AA; 38427 MW; C4A2BDDD4A410C20 CRC64; MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGGYPSPCY QPDRRIQ //