ID   PBX1_MOUSE     STANDARD;      PRT;   430 AA.
AC   P41778;
DT   01-NOV-1995 (Rel. 32, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Pre-B-cell leukemia transcription factor-1 (Homeobox protein PBX1).
GN   Name=Pbx1; Synonyms=Pbx-1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM PBX1B), AND PARTIAL SEQUENCE.
RC   TISSUE=Adrenal gland;
RX   MEDLINE=94308119; PubMed=7913464;
RA   Kagawa N., Ogo A., Takahashi Y., Iwamatsu A., Waterman M.R.;
RT   "A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for
RT   the homeodomain protein Pbx1.";
RL   J. Biol. Chem. 269:18716-18719(1994).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM PBX1A).
RA   Liu Y., MacDonald R.J.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM PBX1A).
RC   STRAIN=C57BL/6; TISSUE=Brain;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   STRUCTURE BY NMR OF 241-294.
RX   MEDLINE=20393887; PubMed=10933814;
RA   Sprules T., Green N., Featherstone M., Gehring K.;
RT   "Conformational changes in the PBX homeodomain and C-terminal
RT   extension upon binding DNA and HOX-derived YPWM peptides(,).";
RL   Biochemistry 39:9943-9950(2000).
CC   -!- FUNCTION: Plays a role in the cAMP-dependent regulation of CYP17
CC       gene expression via its cAMP-regulatory sequence (CRS1) 5'-
CC       ATCAATCAA-3'. Probable positive transcription regulator. May have
CC       a role in steroidogenesis and subsequently sexual development and
CC       differentiation.
CC   -!- SUBCELLULAR LOCATION: Nuclear.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PBX1a;
CC         IsoId=P41778-1; Sequence=Displayed;
CC       Name=PBX1b;
CC         IsoId=P41778-2; Sequence=VSP_002273, VSP_002274;
CC   -!- TISSUE SPECIFICITY: Widely distributed in steroidogenic and non-
CC       steroidogenic cells.
CC   -!- SIMILARITY: Belongs to the TALE/PBX homeobox family.
CC   -!- SIMILARITY: Contains 1 homeobox domain.
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DR   EMBL; L27453; AAA21832.1; -.
DR   EMBL; AF020196; AAB71191.1; -.
DR   EMBL; BC058390; AAH58390.1; -.
DR   PIR; A54863; A54863.
DR   PDB; 1DU6; 16-AUG-00.
DR   PDB; 1LFU; 14-JAN-03.
DR   TRANSFAC; T02088; -.
DR   TRANSFAC; T03451; -.
DR   MGD; MGI:97495; Pbx1.
DR   GO; GO:0005737; C:cytoplasm; IDA.
DR   GO; GO:0005634; C:nucleus; IDA.
DR   GO; GO:0003677; F:DNA binding; IDA.
DR   GO; GO:0005515; F:protein binding; IPI.
DR   GO; GO:0030325; P:adrenal gland development; IMP.
DR   GO; GO:0001658; P:ureteric bud branching; IDA.
DR   GO; GO:0001655; P:urogenital system development; IMP.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR009057; Homeodomain_like.
DR   InterPro; IPR005542; PBX.
DR   InterPro; IPR000685; RuBisCO_large.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF03792; PBX; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   ProDom; PD000010; Homeobox; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
KW   Transcription regulation; DNA-binding; Nuclear protein; Activator;
KW   Homeobox; Alternative splicing; Steroidogenesis;
KW   Sexual differentiation; 3D-structure; Direct protein sequencing.
FT   DOMAIN      127    135       Poly-Ala.
FT   DNA_BIND    233    295       Homeobox; TALE-type.
FT   VARSPLIC    334    347       SSSSFNMSNSGDLF -> GYPSPCYQPDRRIQ (in
FT                                isoform PBX1b).
FT                                /FTId=VSP_002273.
FT   VARSPLIC    348    430       Missing (in isoform PBX1b).
FT                                /FTId=VSP_002274.
FT   TURN        241    243
FT   HELIX       244    254
FT   TURN        255    257
FT   HELIX       263    273
FT   TURN        274    274
FT   HELIX       277    287
FT   TURN        288    290
SQ   SEQUENCE   430 AA;  46626 MW;  AD3FFACBC5A9E715 CRC64;
     MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE
     AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP
     EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM
     NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF
     NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE
     EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG
     AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS ANGGWQDATT PSSVTSPTEG
     PGSVHSDTSN
//