ID PBX1_MOUSE STANDARD; PRT; 430 AA. AC P41778; DT 01-NOV-1995 (Rel. 32, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Pre-B-cell leukemia transcription factor-1 (Homeobox protein PBX1). GN PBX1 OR PBX-1. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. (ISOFORM PBX1B), AND PARTIAL SEQUENCE. RC TISSUE=Adrenal gland; RX MEDLINE=94308119; PubMed=7913464; RA Kagawa N., Ogo A., Takahashi Y., Iwamatsu A., Waterman M.R.; RT "A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for RT the homeodomain protein Pbx1."; RL J. Biol. Chem. 269:18716-18719(1994). RN [2] RP SEQUENCE FROM N.A. (ISOFORM PBX1A). RA Liu Y., MacDonald R.J.; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. RN [3] RP SEQUENCE FROM N.A. (ISOFORM PBX1A). RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP STRUCTURE BY NMR OF 241-294. RX MEDLINE=20393887; PubMed=10933814; RA Sprules T., Green N., Featherstone M., Gehring K.; RT "Conformational changes in the PBX homeodomain and C-terminal RT extension upon binding DNA and HOX-derived YPWM peptides(,)."; RL Biochemistry 39:9943-9950(2000). CC -!- FUNCTION: Plays a role in the cAMP-dependent regulation of CYP17 CC gene expression via its cAMP-regulatory sequence (CRS1) 5'- CC ATCAATCAA-3'. Probable positive transcription regulator. May have CC a role in steroidogenesis and subsequently sexual development and CC differentiation. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=PBX1a; CC IsoId=P41778-1; Sequence=Displayed; CC Name=PBX1b; CC IsoId=P41778-2; Sequence=VSP_002273, VSP_002274; CC -!- TISSUE SPECIFICITY: Widely distributed in steroidogenic and non- CC steroidogenic cells. CC -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. CC -!- SIMILARITY: Contains 1 homeobox domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L27453; AAA21832.1; -. DR EMBL; AF020196; AAB71191.1; -. DR EMBL; BC058390; AAH58390.1; -. DR PIR; A54863; A54863. DR PDB; 1DU6; 16-AUG-00. DR PDB; 1LFU; 14-JAN-03. DR TRANSFAC; T02088; -. DR TRANSFAC; T03451; -. DR MGD; MGI:97495; Pbx1. DR GO; GO:0005737; C:cytoplasm; IDA. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0003677; F:DNA binding; IDA. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0030325; P:adrenal gland development; IMP. DR GO; GO:0001658; P:ureteric bud branching; IDA. DR GO; GO:0001655; P:urogenital system development; IMP. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR005542; PBX. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF03792; PBX; 1. DR PRINTS; PR00024; HOMEOBOX. DR ProDom; PD000010; Homeobox; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW Transcription regulation; DNA-binding; Nuclear protein; Activator; KW Homeobox; Alternative splicing; Steroidogenesis; KW Sexual differentiation; 3D-structure; Direct protein sequencing. FT DOMAIN 127 135 Poly-Ala. FT DNA_BIND 233 295 Homeobox; TALE-type. FT VARSPLIC 334 347 SSSSFNMSNSGDLF -> GYPSPCYQPDRRIQ (in FT isoform PBX1b). FT /FTId=VSP_002273. FT VARSPLIC 348 430 Missing (in isoform PBX1b). FT /FTId=VSP_002274. FT TURN 241 243 FT HELIX 244 254 FT TURN 255 257 FT HELIX 263 273 FT TURN 274 274 FT HELIX 277 287 FT TURN 288 290 SQ SEQUENCE 430 AA; 46626 MW; AD3FFACBC5A9E715 CRC64; MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS ANGGWQDATT PSSVTSPTEG PGSVHSDTSN //