ID PBX1_MOUSE STANDARD; PRT; 347 AA. AC P41778; DT 01-NOV-1995 (REL. 32, CREATED) DT 01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-1 (HOMEOBOX PROTEIN PBX1). GN PBX1 OR PBX-1. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=ADRENAL; RX MEDLINE; 94308119. RA KAGAWA N., OGO A., TAKAHASHI Y., IWAMATSU A., WATERMAN M.R.; RL J. BIOL. CHEM. 269:18716-18719(1994). CC -!- FUNCTION: PLAYS A ROLE IN THE CAMP-DEPENDENT REGULATION OF CYP17 CC GENE EXPRESSION VIA ITS CAMP-REGULATORY SEQUENCE (CRS1) CC 5'-ATCAATCAA-3'. PROBABLE POSITIVE TRANSCRIPTION REGULATOR. MAY CC HAVE A ROLE IN STEROIDOGENESIS AND SUBSEQUENTLY SEXUAL CC DEVELOPMENT AND DIFFERENTIATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- TISSUE SPECIFICITY: WIDELY DISTRIBUTED IN STEROIDOGENIC AND NON- CC STEROIDOGENIC CELLS. CC -!- ALTERNATIVE PRODUCTS: TWO FORMS ARE PRODUCED BY ALTERNATIVE CC SPLICING. CC -!- SIMILARITY: BELONGS TO THE PBX FAMILY OF HOMEOBOX PROTEINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L27453; G456109; -. DR TRANSFAC; T02088; -. DR MGD; MGI:97495; PBX1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW TRANSCRIPTION REGULATION; DNA-BINDING; NUCLEAR PROTEIN; ACTIVATOR; KW HOMEOBOX; ALTERNATIVE SPLICING; STEROIDOGENESIS; KW SEXUAL DIFFERENTIATION. FT DOMAIN 127 135 POLY-ALA. FT DNA_BIND 236 295 HOMEOBOX. SQ SEQUENCE 347 AA; 38427 MW; 8411DDE3 CRC32; MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGGYPSPCY QPDRRIQ //