ID NU4LM_BALMU Reviewed; 98 AA. AC P41301; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 1. DT 24-JAN-2024, entry version 81. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L; OS Balaenoptera musculus (Blue whale). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti; OC Balaenopteridae; Balaenoptera. OX NCBI_TaxID=9771; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8308901; DOI=10.1007/bf00178861; RA Arnason U., Gullberg A.; RT "Comparison between the complete mtDNA sequences of the blue and the fin RT whale, two species that can hybridize in nature."; RL J. Mol. Evol. 37:312-322(1993). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Part of the enzyme membrane arm which is embedded in the CC lipid bilayer and involved in proton translocation. CC {ECO:0000250|UniProtKB:P03901}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000250|UniProtKB:P03901}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092; CC Evidence={ECO:0000250|UniProtKB:P03901}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000250|UniProtKB:P03902}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X72204; CAA51003.1; -; Genomic_DNA. DR PIR; S41828; S41828. DR RefSeq; NP_007064.1; NC_001601.1. DR AlphaFoldDB; P41301; -. DR SMR; P41301; -. DR GeneID; 807737; -. DR CTD; 4539; -. DR OrthoDB; 3030031at2759; -. DR Proteomes; UP000694857; Mitochondrion MT. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR Gene3D; 1.10.287.3510; -; 1. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434:SF0; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L; 1. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane; KW Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..98 FT /note="NADH-ubiquinone oxidoreductase chain 4L" FT /id="PRO_0000118394" FT TRANSMEM 1..21 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 61..81 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 98 AA; 10747 MW; 9F770651FE65ED1B CRC64; MTLIHMNVLM AFSMSLVGLL MYRSHLMSAL LCLEGMMLSL FVLAALTILN SHFTLANMMP IILLVFAAYV AAIGLALLVM VSNTYGTDYV QSLNLLQC //