ID SYG_HUMAN STANDARD; PRT; 685 AA. AC P41250; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE GLYCYL-TRNA SYNTHETASE (EC 6.1.1.14) (GLYCINE--TRNA LIGASE) (GLYRS). GN GARS. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95050870. RA SHIBA K., SCHIMMEL P., MOTEGI H., NODA T.; RL J. BIOL. CHEM. 269:30049-30055(1994). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 95273165. RA WILLIAMS J.H., OSVATH S.R., KHONG T.-F., PEARSE M.J., POWER D.A.; RL NUCLEIC ACIDS RES. 23:1307-1310(1995). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 95050687. RA GE Q., TRIEU E.P., TARGOFF I.N.; RL J. BIOL. CHEM. 269:28790-28797(1994). CC -!- CATALYTIC ACTIVITY: ATP + L-GLYCINE + TRNA(GLY) = AMP + CC PYROPHOSPHATE + L-GLYCYL-TRNA(GLY). CC -!- SUBUNIT: HOMODIMER. CC -!- SIMILARITY: BELONGS TO CLASS-II AMINOACYL-TRNA SYNTHETASES. CC -!- SIMILARITY: CONTAINS ONE COPY OF A DOMAIN THAT WE CALL "WHEP-TRS". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D30658; G1311463; ALT_INIT. DR EMBL; U09510; G493066; -. DR EMBL; U09587; G600727; -. DR MIM; 600287; -. DR PROSITE; PS00179; AA_TRNA_LIGASE_II_1; 1. DR PROSITE; PS00339; AA_TRNA_LIGASE_II_2; FALSE_NEG. DR PROSITE; PS00762; WHEP_TRS; 1. KW AMINOACYL-TRNA SYNTHETASE; PROTEIN BIOSYNTHESIS; LIGASE; ATP-BINDING. FT DOMAIN 20 65 WHEP-TRS. FT CONFLICT 476 476 M -> I (IN REF. 2). SQ SEQUENCE 685 AA; 77530 MW; 36A81DA6 CRC32; MDGAGAEEVL APLRLAVRQQ GDLVRKLKED KAPQVDVDKA VAELKARKRV LEAKELALQP KDDIVDRAKM EDTLKRRFFY DQAFAIYGGV SGLYDFGPVG CALKNNIIQT WRQHFIQEEQ ILEIDCTMLT PEPVLKTSGH VDKFADFMVK DVKNGECFRA DHLLKAHLQK LMSDKKCSVE KKSEMESVLA QLDNYGQQEL ADLFVNYNVK SPITGNDLSP PVSFNLMFKT FIGPGGNMPG YLRPETAQGI FLNFKRLLEF NQGKLPFAAA QIGNSFRNEI SPRSGLIRVR EFTMAEIEHF VDPSEKDHPK FQNVADLHLY LYSAKAQVSG QSARKMRLGD AVEQGVINNT VLGYFIGRIY LYLTKVGISP DKLRFRQHME NEMAHYACDC WDAESKTSYG WIEIVGCADR SCYDLSCHAR ATKVPLVAEK PLKEPKTVNV VQFEPSKGAI GKAYKKDAKL VMEYLAICDE CYITEMEMLL NEKGEFTIET EGKTFQLTKD MINVKRFQKT LYVEEVVPNV IEPSFGLGRI MYTVFEHTFH VREGDEQRTF FSFPAVVAPF KCSVLPLSQN QEFMPFVKEL SEALTRHGVS HKVDDSSGSI GRRYARTDEI GVAFGVTIDF DTVNKTPHTA TLRDRDSMRQ IRAEISELPS IVQDLANGNI TWADVEARYP LFEGQETGKK ETIEE //