ID DRA_HUMAN STANDARD; PRT; 764 AA. AC P40879; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE DRA PROTEIN (DOWN-REGULATED IN ADENOMA). GN DRA. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=COLON; RX MEDLINE; 93248250. RA SCHWEINFEST C.W., HENDERSON K.W., SUSTER S., KONDOH N., PAPAS T.S.; RL PROC. NATL. ACAD. SCI. U.S.A. 90:4166-4170(1993). RN [2] RP SIMILARITY TO SULFATE PERMEASES. RA SANDAL N.N., MARCKER K.A.; RL TRENDS BIOCHEM. SCI. 19:19-19(1994). CC -!- FUNCTION: POSSIBLE SULFATE TRANSPORTER. CC -!- DEVELOPMENTAL STAGE: EXPRESSION IS SIGNIFICANTLY DECREASED IN CC ADENOMAS (POLYPS) AND ADENOCARCINOMAS OF THE COLON. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN (POTENTIAL). CC -!- SIMILARITY: BELONGS TO THE SULFATE PERMEASE FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L02785; L02785. DR MIM; 126650; 11TH EDITION. DR PROSITE; PS01130; SULFATE_TRANSP. KW TRANSPORT; TRANSMEMBRANE. FT TRANSMEM 77 97 POTENTIAL. FT TRANSMEM 100 120 POTENTIAL. FT TRANSMEM 125 145 POTENTIAL. FT TRANSMEM 176 196 POTENTIAL. FT TRANSMEM 198 218 POTENTIAL. FT TRANSMEM 259 279 POTENTIAL. FT TRANSMEM 286 306 POTENTIAL. FT TRANSMEM 343 363 POTENTIAL. FT TRANSMEM 375 395 POTENTIAL. FT TRANSMEM 412 432 POTENTIAL. FT TRANSMEM 439 459 POTENTIAL. FT TRANSMEM 470 490 POTENTIAL. FT TRANSMEM 644 664 POTENTIAL. FT TRANSMEM 702 722 POTENTIAL. SQ SEQUENCE 764 AA; 84504 MW; 3123001 CN; MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA KRIVLSLFPI ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI PPVYGLYASF FPAIIYLFFG TSRHISVGPF PILSMMVGLA VSGAVSKAVP DRNATTLGLP NNSNNSSLLD DERVRVAAAA SVTVLSGIIQ LAFGILRIGF VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP VSIFKVLYSV FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA FAVAFSVASV YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS AVQESTGGKT QIAGLIGAII VLIVVLAIGF LLAPLQKSVL AALALGNLKG MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI VLGLGLGLAA SVAFQLLTIV FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC PSPIYFANIG FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI LDFSAVSFLD VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF DGEVKSSIFF LTIHDAVLHI LMKKDYSTSK FNPSQEKDGK IDFTINTNGG LRNRVYEVPV ETKF //